Grace OCallaghan
Overview
Explore the profile of Grace OCallaghan including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
8
Citations
310
Followers
0
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Recent Articles
1.
Keane J, Fernandes P, Kratz F, OCallaghan G, Gahan C, Joyce S, et al.
Pharmacol Res Perspect
. 2024 Jun;
12(4):e1226.
PMID: 38886975
Although classically recognized as a neurotransmitter, gamma aminobutyric acid (GABA) has also been identified in colonic tumors. Moreover, the gut microbiome represents another potential source of GABA. Both GABA and...
2.
OConnell Motherway M, Houston A, OCallaghan G, Reunanen J, OBrien F, ODriscoll T, et al.
Mol Microbiol
. 2018 Oct;
111(1):287-301.
PMID: 30352131
Development of the human gut microbiota commences at birth, with certain bifidobacterial species representing dominant and early colonisers of the newborn gastrointestinal tract. The molecular basis of Bifidobacterium colonisation, persistence...
3.
Ronan N, Einarsson G, Twomey M, Mooney D, Mullane D, NiChroinin M, et al.
Chest
. 2017 Oct;
153(2):395-403.
PMID: 29037527
Background: Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at the Cork CF Centre is 23%. This study assessed...
4.
Ronan N, Fleming C, OCallaghan G, Maher M, Murphy D, Plant B
Chest
. 2015 Sep;
148(3):e72-e75.
PMID: 26324139
Cystic fibrosis (CF) conductance transmembrane regulator functions as a chloride (Cl-) channel in multiple organs, including the lungs. More than 1,800 disease-associated mutations have been identified, which can be divided...
5.
Fouhy F, Deane J, Rea M, OSullivan O, Ross R, OCallaghan G, et al.
PLoS One
. 2015 Mar;
10(3):e0119355.
PMID: 25748176
Background: High-throughput sequencing has enabled detailed insights into complex microbial environments, including the human gut microbiota. The accuracy of the sequencing data however, is reliant upon appropriate storage of the...
6.
Quinn E, Wang J, OCallaghan G, Redmond H
PLoS One
. 2013 May;
8(4):e62232.
PMID: 23638011
TLR signaling is a crucial component of the innate immune response to infection. MicroRNAs (miRNAs) have been shown to be upregulated during TLR signaling. Specifically, microRNA-146a (miR-146a) plays a key...
7.
Brint E, OCallaghan G, Houston A
Cell Mol Life Sci
. 2013 Apr;
70(21):4085-99.
PMID: 23579628
Fas, also known as CD95 or APO-1, is a member of the tumor necrosis factor/nerve growth factor superfamily. Although best characterized in terms of its apoptotic function, recent studies have...
8.
OCallaghan G, Ryan A, Neary P, OMahony C, Shanahan F, Houston A
Int J Cancer
. 2013 Feb;
133(4):825-34.
PMID: 23390011
Despite studies demonstrating that inhibition of cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2 ) has significant chemotherapeutic benefits in vitro and in vivo, inhibition of COX enzymes is associated with serious gastrointestinal...