Govindan Raghunathan
Overview
Explore the profile of Govindan Raghunathan including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
161
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Recent Articles
1.
A DNA Polymerase Variant Senses the Epigenetic Marker 5-Methylcytosine by Increased Misincorporation
Henkel M, Fillbrunn A, Marchand V, Raghunathan G, Berthold M, Motorin Y, et al.
Angew Chem Int Ed Engl
. 2024 Oct;
63(48):e202413304.
PMID: 39449390
Dysregulation of DNA methylation is associated with human disease, particularly cancer, and the assessment of aberrant methylation patterns holds great promise for clinical diagnostics. However, DNA polymerases do not effectively...
2.
Soundrarajan N, Park S, Le Van Chanh Q, Cho H, Raghunathan G, Ahn B, et al.
Sci Rep
. 2019 Aug;
9(1):11569.
PMID: 31399625
Porcine protegrin-1 (PG-1) is a broad-spectrum antimicrobial peptide (AMP) with potent antimicrobial activities. We produced recombinant PG-1 and evaluated its cytotoxicity toward various types of mammalian cell lines, including embryonic...
3.
Raghunathan G, Marx A
Sci Rep
. 2019 Jan;
9(1):590.
PMID: 30679705
DNA polymerases the key enzymes for several biotechnological applications. Obviously, nature has not evolved these enzymes to be compatible with applications in biotechnology. Thus, engineering of a natural scaffold of...
4.
Madan B, Sokalingam S, Raghunathan G, Lee S
Proteins
. 2014 Jul;
82(10):2812-22.
PMID: 25044033
Both Type I' and Type II' β-turns have the same sense of the β-turn twist that is compatible with the β-sheet twist. They occur predominantly in two residue β-hairpins, but...
5.
Raghunathan G, Munussami G, Moon H, Paik H, An S, Kim Y, et al.
Microb Cell Fact
. 2014 Jun;
13:68.
PMID: 24885571
Background: Inclusion bodies (IBs) were generally considered to be inactive protein deposits and did not hold any attractive values in biotechnological applications. Recently, some IBs of recombinant proteins were confirmed...
6.
Raghunathan G, Sokalingam S, Soundrarajan N, Madan B, Munussami G, Lee S
Mol Biosyst
. 2013 Jul;
9(9):2379-89.
PMID: 23861008
An attempt to alter protein surface charges through traditional protein engineering approaches often affects the native protein structure significantly and induces misfolding. This limitation is a major hindrance in modulating...
7.
Raghunathan G, Soundrarajan N, Sokalingam S, Yun H, Lee S
PLoS One
. 2012 Dec;
7(12):e51510.
PMID: 23240034
Diversification of protein sequence-structure space is a major concern in protein engineering. Deletion mutagenesis can generate a protein sequence-structure space different from substitution mutagenesis mediated space, but it has not...
8.
Soundrarajan N, Sokalingam S, Raghunathan G, Budisa N, Paik H, Yoo T, et al.
PLoS One
. 2012 Oct;
7(10):e46741.
PMID: 23056430
N-terminal site-specific modification of a protein has many advantages over methods targeting internal positions, but it is not easy to install reactive groups onto a protein in an N-terminal specific...
9.
Sokalingam S, Raghunathan G, Soundrarajan N, Lee S
PLoS One
. 2012 Jul;
7(7):e40410.
PMID: 22792305
Two positively charged basic amino acids, arginine and lysine, are mostly exposed to protein surface, and play important roles in protein stability by forming electrostatic interactions. In particular, the guanidinium...