Glenn S Van Aller
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Explore the profile of Glenn S Van Aller including associated specialties, affiliations and a list of published articles.
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17
Citations
2409
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Recent Articles
11.
Van Aller G, Reynoird N, Barbash O, Huddleston M, Liu S, Zmoos A, et al.
Epigenetics
. 2012 Mar;
7(4):340-3.
PMID: 22419068
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is...
12.
Totoritis R, Duraiswami C, Taylor A, Kerrigan J, Campobasso N, Smith K, et al.
Biochemistry
. 2011 Jun;
50(31):6642-54.
PMID: 21711014
The continual bacterial adaptation to antibiotics creates an ongoing medical need for the development of novel therapeutics. Polypeptide deformylase (PDF) is a highly conserved bacterial enzyme, which is essential for...
13.
Van Aller G, Carson J, Tang W, Peng H, Zhao L, Copeland R, et al.
Biochem Biophys Res Commun
. 2011 Feb;
406(2):194-9.
PMID: 21300025
The PI3K signaling pathway is activated in a broad spectrum of human cancers, either directly by genetic mutation or indirectly via activation of receptor tyrosine kinases or inactivation of the...
14.
Van Aller G, Carson J, Fernandes C, Lehr R, Sinnamon R, Kirkpatrick R, et al.
Anal Biochem
. 2008 Sep;
383(2):311-5.
PMID: 18814837
Differential activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway has been linked to cancer. Activation occurs through gene amplification and activating mutations. High-frequency mutations in the gene encoding the p110alpha catalytic...
15.
Huang J, Van Aller G, Taylor A, Kerrigan J, Liu W, Trulli J, et al.
J Bacteriol
. 2006 Jul;
188(14):5249-57.
PMID: 16816197
Legionella pneumophila is a gram-negative facultative intracellular human pathogen that can cause fatal Legionnaires' disease. Polypeptide deformylase (PDF) is a novel broad-spectrum antibacterial target, and reports of inhibitors of PDF...
16.
Van Aller G, Nandigama R, Petit C, DeWolf Jr W, Quinn C, Aubart K, et al.
Biochemistry
. 2005 Jan;
44(1):253-60.
PMID: 15628866
Polypeptide deformylase (PDF) is an essential bacterial metalloenzyme responsible for the removal of the N-formyl group from the N-terminal methionine of nascent polypeptides. Inhibition of bacterial PDF enzymes by actinonin,...
17.
Daines R, Pendrak I, Sham K, Van Aller G, Konstantinidis A, Lonsdale J, et al.
J Med Chem
. 2002 Dec;
46(1):5-8.
PMID: 12502353
The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead...