Glen Clack
Overview
Explore the profile of Glen Clack including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
1694
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0
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Recent Articles
11.
Khoja L, Shenjere P, Hodgson C, Hodgetts J, Clack G, Hughes A, et al.
Melanoma Res
. 2013 Nov;
24(1):40-6.
PMID: 24201293
We previously demonstrated that circulating tumour cells (CTCs) are detectable by the MelCAM and high molecular weight melanoma-associated antigen (HMW-MAA)-dependent CellSearch platform. However, CTCs which do not express these capture...
12.
Khoja L, Lorigan P, Zhou C, Lancashire M, Booth J, Cummings J, et al.
J Invest Dermatol
. 2012 Dec;
133(6):1582-90.
PMID: 23223143
The incidence of melanoma is increasing worldwide. Advances in targeted agents and immunotherapy have improved outcomes in metastatic disease, but biomarkers are required to optimize treatment. We determined the prevalence...
13.
Van Poznak C, Makris A, Clack G, Barlow D, Eastell R
Breast Cancer Res Treat
. 2012 Jul;
134(3):1141-7.
PMID: 22763465
Lipid profiles in women with early breast cancer receiving anastrozole with or without risedronate were examined within an international Phase III/IV study to assess for possible treatment related changes. Postmenopausal...
14.
Hannon R, Finkelman R, Clack G, Iacona R, Rimmer M, Gossiel F, et al.
Bone
. 2012 Jan;
50(4):885-92.
PMID: 22245630
Saracatinib (AZD0530) is an orally active once-daily Src kinase inhibitor which modulates key signaling pathways in cancer cells. In a Phase I study in patients with advanced solid malignancies resistant...
15.
Krebs M, Hou J, Sloane R, Lancashire L, Priest L, Nonaka D, et al.
J Thorac Oncol
. 2011 Dec;
7(2):306-15.
PMID: 22173704
Introduction: Epithelial circulating tumor cells (CTCs) are detectable in patients with non-small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely reported prerequisite for metastasis, may lead to...
16.
Krebs M, Sloane R, Priest L, Lancashire L, Hou J, Greystoke A, et al.
J Clin Oncol
. 2011 Mar;
29(12):1556-63.
PMID: 21422424
Purpose: Lung cancer is the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC) lacks validated biomarkers to predict treatment response. This study investigated whether circulating tumor cells (CTCs)...
17.
Hou J, Krebs M, Ward T, Sloane R, Priest L, Hughes A, et al.
Am J Pathol
. 2011 Mar;
178(3):989-96.
PMID: 21356352
Circulating tumor cell (CTC) number in metastatic cancer patients yields prognostic information consistent with enhanced cell migration and invasion via loss of adhesion, a feature of epithelial-to-mesenchymal transition (EMT). Tumor...
18.
Van Poznak C, Hannon R, Mackey J, Campone M, Apffelstaedt J, Clack G, et al.
J Clin Oncol
. 2010 Jan;
28(6):967-75.
PMID: 20065185
PURPOSE To investigate the management of bone health in women with early breast cancer (EBC) who were scheduled to receive anastrozole. PATIENTS AND METHODS Postmenopausal women with hormone receptor-positive EBC...
19.
Hannon R, Clack G, Rimmer M, Swaisland A, Lockton J, Finkelman R, et al.
J Bone Miner Res
. 2009 Sep;
25(3):463-71.
PMID: 19775203
Src is a nonreceptor tyrosine kinase thought to be essential for osteoclast function and bone resorption. We investigated the effect of the orally available Src inhibitor saracatinib (AZD0530) on bone...
20.
Hodgson D, Whittaker R, Herath A, Amakye D, Clack G
Mol Oncol
. 2009 Apr;
3(1):24-32.
PMID: 19383364
Biomarker measurements have become an essential component of oncology drug development, particularly so in this era of targeted therapies. Such measurements ensure that clinical studies are testing our biological hypotheses...