Gleb P Tolstykh
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Explore the profile of Gleb P Tolstykh including associated specialties, affiliations and a list of published articles.
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25
Citations
436
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Recent Articles
11.
Thompson G, Roth C, Kuipers M, Tolstykh G, Beier H, Ibey B
Biochem Biophys Res Commun
. 2016 Jan;
470(1):35-40.
PMID: 26721436
Permeabilization of cell membranes occurs upon exposure to a threshold absorbed dose (AD) of nanosecond pulsed electric fields (nsPEF). The ultimate, physiological bioeffect of this exposure depends on the type...
12.
Beier H, Tolstykh G, Musick J, Thomas R, Ibey B
J Neural Eng
. 2014 Oct;
11(6):066006.
PMID: 25340253
Objective: Short infrared (IR) laser pulses have been used to stimulate action potentials in neurons both in vivo and in vitro. However, the mechanism(s) underlying this phenomenon has remained elusive....
13.
Tolstykh G, Beier H, Roth C, Thompson G, Ibey B
Bioelectrochemistry
. 2014 Feb;
100:80-7.
PMID: 24530104
The interaction between nsPEF-induced Ca(2+) release and nsPEF-induced phosphatidylinositol4,5-bisphosphate (PIP2) hydrolysis is not well understood. To better understand this interrelation we monitored intracellular calcium changes, in cells loaded with Calcium...
14.
Bunegin L, Tolstykh G, Gelineau J, Cosimi A, Anderson L
ASAIO J
. 2013 Jul;
59(4):427-32.
PMID: 23820283
Hypothermic machine perfusion (HMP) for the preservation of kidneys, recovered from extended criteria organ donors (ECDs), presents the opportunity for assessing ex vivo parameters that may have value in predicting...
15.
Tolstykh G, Beier H, Roth C, Thompson G, Payne J, Kuipers M, et al.
Bioelectrochemistry
. 2013 Jun;
94:23-9.
PMID: 23747521
Exposure to nanosecond pulsed electrical fields (nsPEFs) results in a myriad of observable effects in mammalian cells. While these effects are often attributed to the direct permeabilization of both the...
16.
Roth C, Tolstykh G, Payne J, Kuipers M, Thompson G, Desilva M, et al.
J Biomed Opt
. 2013 Mar;
18(3):035005.
PMID: 23532338
The persistent influx of ions through nanopores created upon cellular exposure to nanosecond pulse electric fields (nsPEF) could be used to modulate neuronal function. One ion, calcium (Ca(2+)), is important...
17.
Tolstykh G, Cavazos J
Epilepsy Behav
. 2013 Jan;
26(3):410-4.
PMID: 23305781
Sudden unexpected death in epilepsy (SUDEP) accounts for 15% of all deaths in people with epilepsy and 50% in refractory epilepsy. The underlying mechanisms are not well understood, but seizure-induced...
18.
Beier H, Roth C, Tolstykh G, Ibey B
Biochem Biophys Res Commun
. 2012 Jun;
423(4):863-6.
PMID: 22713455
Exposure of cells to nanosecond pulsed electric fields (nsPEF) causes a rapid increase in intracellular calcium. The mechanism(s) responsible for this calcium burst remains unknown, but is hypothesized to be...
19.
Zhang K, Tolstykh G, Sanchez R, Cavazos J
Aging Dis
. 2012 Mar;
2(4):332-8.
PMID: 22396885
Emerging data indicate that age-related brain changes alter seizure susceptibility, seizure-associated neurodegeneration, and responsiveness to AEDs. The present study assessed long-term animal survival in the Kainic Acid (KA) model along...
20.
Tolstykh G, Gelineau J, Maier L, Bunegin L
Ann Transplant
. 2010 Sep;
15(3):35-43.
PMID: 20877265
Background: A reliable, portable, cost effective device for perfusion preservation of donor organs remains elusive. A portable, organ perfusion device design for hypothermic, machine perfusion (HMP) that successfully supported rodent...