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» Authors » Giuseppina Cappiello

Giuseppina Cappiello

Explore the profile of Giuseppina Cappiello including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 25
Citations 234
Followers 0
Related Specialties
Infectious Diseases
Microbiology
Gastroenterology
Top 10 Co-Authors
Alberto Spano
Roberta Longo
Valentina Svicher
Romina Salpini
Ada Bertoli
Francesca Ceccherini-Silberstein
Carlo Federico Perno
Isabella Abbate
Massimo Andreoni
Maria R Capobianchi
Published In
Dig Liver Dis
J Infect
J Hepatol
Viruses
Biomedicines
Affiliations
Soon will be listed here.
Recent Articles
1.
Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies
Piermatteo L, DAnna S, Bertoli A, Bellocchi M, Carioti L, Fabeni L, et al.
Emerg Microbes Infect . 2023 Jun; 12(1):2219347. PMID: 37288750
Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize...
2.
HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV Reactivation
Piermatteo L, Alkhatib M, DAnna S, Malagnino V, Bertoli A, Andreassi E, et al.
Biomedicines . 2021 Oct; 9(10). PMID: 34680469
HBeAg is a marker of HBV-activity, and HBeAg-loss predicts a favorable clinical outcome. Here, we characterize HBeAg-levels across different phases of HBV infection, their correlation with virological/biochemical markers and the...
3.
West Nile and Usutu viruses co-circulation in central Italy: outcomes of the 2018 integrated surveillance
Scaramozzino P, Carvelli A, Bruni G, Cappiello G, Censi F, Magliano A, et al.
Parasit Vectors . 2021 May; 14(1):243. PMID: 33962673
Background: West Nile (WNV) and Usutu (USUV) are emerging vector-borne zoonotic flaviviruses. They are antigenically very similar, sharing the same life cycle with birds as amplification host, Culicidae as vector,...
4.
Expanding Usutu virus circulation in Italy: detection in the Lazio region, central Italy, 2017 to 2018
Carletti F, Colavita F, Rovida F, Percivalle E, Baldanti F, Ricci I, et al.
Euro Surveill . 2019 Jan; 24(3). PMID: 30670139
Blood donation screening for West Nile virus (WNV) was mandatory in the Lazio region in 2017 and 2018 (June-November) according to the national surveillance plan. In these years, all five...
5.
HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets
Colagrossi L, Salpini R, Scutari R, Carioti L, Battisti A, Piermatteo L, et al.
Viruses . 2018 Jul; 10(7). PMID: 29987240
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV...
6.
Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro
Salpini R, Surdo M, Warner N, Cortese M, Colledge D, Soppe S, et al.
Oncotarget . 2017 Feb; 8(9):15704-15715. PMID: 28152517
Background: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. Methods: This study...
7.
Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection
Mirabelli C, Surdo M, van Hemert F, Lian Z, Salpini R, Cento V, et al.
J Infect . 2014 Dec; 70(3):288-98. PMID: 25452041
Background: To define HBsAg-mutations correlated with different serum HBV-DNA levels in HBV chronically-infected drug-naive patients. Methods: This study included 187 patients stratified into the following ranges of serum HBV-DNA:12-2000 IU/ml,...
8.
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen
Cento V, van Hemert F, Neumann-Fraune M, Mirabelli C, Di Maio V, Salpini R, et al.
J Infect . 2013 Jun; 67(4):303-12. PMID: 23796863
Introduction: The identification of novel reverse-transcriptase (RT) drug-resistance mutations is critical in predicting the probability of success to anti-HBV treatment. Furthermore, due to HBV-RT/HBsAg gene-overlap, they can have an impact...
9.
Overlapping structure of hepatitis B virus (HBV) genome and immune selection pressure are critical forces modulating HBV evolution
Cento V, Mirabelli C, Dimonte S, Salpini R, Han Y, Trimoulet P, et al.
J Gen Virol . 2012 Oct; 94(Pt 1):143-149. PMID: 23052389
How the overlap between the hepatitis B virus (HBV) reverse transcriptase (RT) and HBV S antigen (HBsAg) genes modulates the extent of HBV genetic variability is still an open question,...
10.
Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection
Svicher V, Cento V, Bernassola M, Neumann-Fraune M, van Hemert F, Chen M, et al.
Antiviral Res . 2011 Nov; 93(1):86-93. PMID: 22086128
Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg...