Giulia Schiroli
Overview
Explore the profile of Giulia Schiroli including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
870
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Recent Articles
1.
Schiroli G, Kartha V, Duarte F, Kristiansen T, Mayerhofer C, Shrestha R, et al.
Nat Commun
. 2024 May;
15(1):4325.
PMID: 38773071
Hematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using...
2.
Kfoury Y, Ji F, Jain E, Mazzola M, Schiroli G, Papazian A, et al.
Blood Adv
. 2023 Jul;
7(21):6608-6623.
PMID: 37450380
Myelodysplastic syndromes (MDSs) are a heterogenous group of diseases affecting the hematopoietic stem cell that are curable only by stem cell transplantation. Both hematopoietic cell intrinsic changes and extrinsic signals...
3.
Rhee C, Scadden E, Wong L, Schiroli G, Mazzola M, Chea P, et al.
Blood
. 2023 Jun;
142(7):658-674.
PMID: 37267513
Myeloid cell heterogeneity is known, but whether it is cell-intrinsic or environmentally-directed remains unclear. Here, an inducible/reversible system pausing myeloid differentiation allowed the definition of clone-specific functions that clustered monocytes...
4.
Elferich J, Schiroli G, Scadden D, Grigorieff N
Elife
. 2022 Nov;
11.
PMID: 36382886
A major goal of biological imaging is localization of biomolecules inside a cell. Fluorescence microscopy can localize biomolecules inside whole cells and tissues, but its ability to count biomolecules and...
5.
McAlpine C, Kiss M, Zuraikat F, Cheek D, Schiroli G, Amatullah H, et al.
J Exp Med
. 2022 Sep;
219(11).
PMID: 36129517
A sleepless night may feel awful in its aftermath, but sleep's revitalizing powers are substantial, perpetuating the idea that convalescent sleep is a consequence-free physiological reset. Although recent studies have...
6.
Cesana D, Calabria A, Rudilosso L, Gallina P, Benedicenti F, Spinozzi G, et al.
Nat Med
. 2021 Jun;
27(8):1458-1470.
PMID: 34140705
Gene therapy (GT) has rapidly attracted renewed interest as a treatment for otherwise incurable diseases, with several GT products already on the market and many more entering clinical testing for...
7.
Vavassori V, Mercuri E, Marcovecchio G, Castiello M, Schiroli G, Albano L, et al.
EMBO Mol Med
. 2021 Jan;
13(3):e13545.
PMID: 33475257
Precise correction of the CD40LG gene in T cells and hematopoietic stem/progenitor cells (HSPC) holds promise for treating X-linked hyper-IgM Syndrome (HIGM1), but its actual therapeutic potential remains elusive. Here,...
8.
Schiroli G, Conti A, Ferrari S, Della Volpe L, Jacob A, Albano L, et al.
Cell Stem Cell
. 2019 Mar;
24(4):551-565.e8.
PMID: 30905619
Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for treating genetic diseases. However, responses triggered by programmable nucleases in HSPCs are poorly characterized and may negatively...
9.
Petrillo C, Thorne L, Unali G, Schiroli G, Giordano A, Piras F, et al.
Cell Stem Cell
. 2018 Nov;
23(6):820-832.e9.
PMID: 30416070
Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively...
10.
Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, et al.
Sci Transl Med
. 2017 Oct;
9(411).
PMID: 29021165
Targeted genome editing in hematopoietic stem/progenitor cells (HSPCs) is an attractive strategy for treating immunohematological diseases. However, the limited efficiency of homology-directed editing in primitive HSPCs constrains the yield of...