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Gilles R X Hickson

Explore the profile of Gilles R X Hickson including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 879
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Recent Articles
1.
Carim S, Hickson G
iScience . 2023 Jun; 26(6):106903. PMID: 37378349
Animal cell cytokinesis requires activation of the GTPase RhoA (Rho1 in ), which assembles an F-actin- and myosin II-dependent contractile ring (CR) at the equatorial plasma membrane. CR closure is...
2.
Hickson G
J Cell Biol . 2022 Feb; 221(3). PMID: 35191950
During cytokinesis, microtubules become compacted into a dense midbody prior to abscission. Using genetic perturbations and imaging of C. elegans zygotes, Hirsch et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202011085) uncover an...
3.
Carim S, Kechad A, Hickson G
Front Cell Dev Biol . 2020 Oct; 8:575226. PMID: 33117802
Cytokinesis is the last step of cell division that partitions the cellular organelles and cytoplasm of one cell into two. In animal cells, cytokinesis requires Rho-GTPase-dependent assembly of F-actin and...
4.
El-Amine N, Carim S, Wernike D, Hickson G
Mol Biol Cell . 2019 Jun; 30(17):2185-2204. PMID: 31166845
Rho-dependent proteins control assembly of the cytokinetic contractile ring, yet it remains unclear how those proteins guide ring closure and how they promote subsequent formation of a stable midbody ring....
5.
Jananji S, Risi C, Lindamulage I, Picard L, Van Sciver R, Laflamme G, et al.
J Mol Biol . 2017 Feb; 429(5):715-731. PMID: 28147230
Cytokinesis of animal cells requires the assembly of a contractile ring, which promotes daughter cell splitting. Anillin is a conserved scaffold protein involved in organizing the structural components of the...
6.
Neveu B, Spinella J, Richer C, Lagace K, Cassart P, Lajoie M, et al.
Haematologica . 2016 Aug; 101(12):1534-1543. PMID: 27540136
The most common rearrangement in childhood precursor B-cell acute lymphoblastic leukemia is the t(12;21)(p13;q22) translocation resulting in the ETV6-AML1 fusion gene. A frequent concomitant event is the loss of the...
7.
Rodrigues N, Lekomtsev S, Jananji S, Kriston-Vizi J, Hickson G, Baum B
Nature . 2015 Jul; 524(7566):489-92. PMID: 26168397
Cell division requires the precise coordination of chromosome segregation and cytokinesis. This coordination is achieved by the recruitment of an actomyosin regulator, Ect2, to overlapping microtubules at the centre of...
8.
El Amine N, Kechad A, Jananji S, Hickson G
J Cell Biol . 2013 Nov; 203(3):487-504. PMID: 24217622
During cytokinesis, closure of the actomyosin contractile ring (CR) is coupled to the formation of a midbody ring (MR), through poorly understood mechanisms. Using time-lapse microscopy of Drosophila melanogaster S2...
9.
Kechad A, Jananji S, Ruella Y, Hickson G
Curr Biol . 2012 Jan; 22(3):197-203. PMID: 22226749
Animal cell cytokinesis proceeds via constriction of an actomyosin-based contractile ring (CR) [1, 2]. Upon reaching a diameter of ~1 μm [3], a midbody ring (MR) forms to stabilize the...
10.
Hickson G, OFarrell P
Biochem Soc Trans . 2008 May; 36(Pt 3):439-41. PMID: 18481976
Cytokinesis is a dynamic and plastic process involving the co-ordinated regulation of many components. Accordingly, many proteins, including the putative scaffold protein anillin, localize to the cleavage furrow and are...