Gijs A Versteeg
Overview
Explore the profile of Gijs A Versteeg including associated specialties, affiliations and a list of published articles.
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26
Citations
1458
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Recent Articles
1.
Bestehorn A, von Wiren J, Zeiler C, Fesselet J, Didusch S, Forte M, et al.
Mol Cell
. 2025 Jan;
85(4):742-755.e9.
PMID: 39862867
The fidelity of immune responses depends on timely controlled and selective mRNA degradation that is largely driven by RNA-binding proteins (RBPs). It remains unclear whether stochastic or directed processes govern...
2.
Kettel P, Marosits L, Spinetti E, Rechberger M, Giannini C, Radler P, et al.
EMBO J
. 2024 Sep;
43(20):4668-4698.
PMID: 39232130
Conserved signaling cascades monitor protein-folding homeostasis to ensure proper cellular function. One of the evolutionary conserved key players is IRE1, which maintains endoplasmic reticulum (ER) homeostasis through the unfolded protein...
3.
Schwartz I, Vunjak M, Budroni V, Cantoran Garcia A, Mastrovito M, Soderholm A, et al.
Elife
. 2023 Aug;
12.
PMID: 37622993
Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon...
4.
Scinicariello S, Soderholm A, Schafer M, Shulkina A, Schwartz I, Hacker K, et al.
Elife
. 2023 Mar;
12.
PMID: 36961408
Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay. A key but poorly understood...
5.
Ehrmann J, Grabarczyk D, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, et al.
Science
. 2023 Feb;
379(6637):1117-1123.
PMID: 36758105
Inhibitor of apoptosis proteins (IAPs) bind to pro-apoptotic proteases, keeping them inactive and preventing cell death. The atypical ubiquitin ligase BIRC6 is the only essential IAP, additionally functioning as a...
6.
de Almeida M, Hinterndorfer M, Brunner H, Grishkovskaya I, Singh K, Schleiffer A, et al.
Nature
. 2021 Oct;
599(7885):491-496.
PMID: 34711951
Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and temporal regulation of cellular processes. To systematically elucidate such gene...
7.
Watzenboeck M, Drobits B, Zahalka S, Gorki A, Farhat A, Quattrone F, et al.
PLoS Pathog
. 2021 Apr;
17(4):e1009487.
PMID: 33905460
Lipocalin 2 (LCN2) is a secreted glycoprotein with roles in multiple biological processes. It contributes to host defense by interference with bacterial iron uptake and exerts immunomodulatory functions in various...
8.
Budroni V, Versteeg G
Viruses
. 2021 Apr;
13(4).
PMID: 33808506
The rapid and dynamic activation of the innate immune system is achieved through complex signaling networks regulated by post-translational modifications modulating the subcellular localization, activity, and abundance of signaling molecules....
9.
Hacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg G
Sci Rep
. 2019 May;
9(1):7901.
PMID: 31133683
Tripartite motif protein 52 (TRIM52) is a non-canonical TRIM family member harbouring the largest RING domain encoded in the human genome. In humans TRIM52 is conserved and has been under...
10.
Vunjak M, Versteeg G
Curr Biol
. 2019 Jan;
29(2):R42-R44.
PMID: 30668943
Vunjak and Versteeg introduce the TRIM family of post-translational modifiers and the roles of these proteins in viral restriction, immune signaling and autophagy.