Gianvito Arpino
Overview
Explore the profile of Gianvito Arpino including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
219
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0
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Recent Articles
1.
Wang X, Arpino G, Mohseni A, Bleck C, Wu L
Biophys J
. 2025 Jan;
PMID: 39810419
Dense-core vesicles (DCVs) are found in various types of cells, such as neurons, pancreatic β- cells, and chromaffin cells. These vesicles release transmitters, peptides, and hormones to regulate diverse functions,...
2.
Wei L, Guo X, Haimov E, Obashi K, Lee S, Shin W, et al.
Cell Discov
. 2024 Jun;
10(1):62.
PMID: 38862506
Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, to form Ω-shape profiles and...
3.
Ge L, Shin W, Arpino G, Wei L, Chan C, Bleck C, et al.
Sci Adv
. 2022 Jun;
8(24):eabm6049.
PMID: 35714180
Vesicle fusion at preestablished plasma membrane release sites releases transmitters and hormones to mediate fundamental functions like neuronal network activities and fight-or-flight responses. This half-a-century-old concept-fusion at well-established release sites...
4.
Guo X, Han S, Wei L, Arpino G, Shin W, Wang X, et al.
STAR Protoc
. 2022 May;
3(2):101404.
PMID: 35600934
Real-time confocal and super-resolution imaging reveals membrane dynamics of exo- and endocytosis, including hemi-fusion, fusion pore opening, expansion, constriction, closure (kiss-and-run), fused-vesicle shrinking (shrink fusion), and flat membrane transition to...
5.
Arpino G, Somasundaram A, Shin W, Ge L, Villareal S, Chan C, et al.
iScience
. 2022 Feb;
25(2):103809.
PMID: 35198874
Clathrin-mediated endocytosis, the most prominent endocytic mode, is thought to be generated primarily from relatively flat patches of the plasma membrane. By employing conventional and platinum replica electron microscopy and...
6.
Shin W, Wei L, Arpino G, Ge L, Guo X, Chan C, et al.
Neuron
. 2021 Aug;
109(19):3119-3134.e5.
PMID: 34411513
Transformation of flat membrane into round vesicles is generally thought to underlie endocytosis and produce speed-, amount-, and vesicle-size-specific endocytic modes. Visualizing depolarization-induced exocytic and endocytic membrane transformation in live...
7.
Shin W, Arpino G, Thiyagarajan S, Su R, Ge L, McDargh Z, et al.
Cell Rep
. 2020 Jan;
30(2):421-431.e7.
PMID: 31940486
For decades, two fusion modes were thought to control hormone and transmitter release essential to life; one facilitates release via fusion pore dilation and flattening (full collapse), and the other...
8.
Shin W, Ge L, Arpino G, Villarreal S, Hamid E, Liu H, et al.
Cell
. 2018 Apr;
173(4):934-945.e12.
PMID: 29606354
Fusion is thought to open a pore to release vesicular cargoes vital for many biological processes, including exocytosis, intracellular trafficking, fertilization, and viral entry. However, fusion pores have not been...
9.
Wen P, Grenklo S, Arpino G, Tan X, Liao H, Heureaux J, et al.
Nat Commun
. 2016 Sep;
7:12604.
PMID: 27576662
Vesicle fusion is executed via formation of an Ω-shaped structure (Ω-profile), followed by closure (kiss-and-run) or merging of the Ω-profile into the plasma membrane (full fusion). Although Ω-profile closure limits...