Giancarlo Solaini
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Explore the profile of Giancarlo Solaini including associated specialties, affiliations and a list of published articles.
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55
Citations
2899
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Recent Articles
1.
Grandi M, Fabbian S, Solaini G, Baracca A, Bellanda M, Giorgio V
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38731874
The mitochondrial protein IF1 is upregulated in many tumors and acts as a pro-oncogenic protein through its interaction with the ATP synthase and the inhibition of apoptosis. We have recently...
2.
Grandi M, Galber C, Gatto C, Nobile V, Pucci C, Schaldemose Nielsen I, et al.
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542395
Mitochondria are involved in multiple aspects of neurodevelopmental processes and play a major role in the pathogenetic mechanisms leading to neuro-degenerative diseases. Fragile-X-related disorders (FXDs) are genetic conditions that occur...
3.
Del Dotto V, Musiani F, Baracca A, Solaini G
Int J Mol Sci
. 2024 Feb;
25(4).
PMID: 38396915
Mitochondrial ATP synthase (Complex V) catalyzes the last step of oxidative phosphorylation and provides most of the energy (ATP) required by human cells. The mitochondrial genes and encode two subunits...
4.
Righetti R, Grillini S, Del Dotto V, Costanzini A, Liuzzi F, Zanna C, et al.
Int J Mol Sci
. 2023 Oct;
24(19).
PMID: 37834071
Cancer cells overexpress IF, the endogenous protein that inhibits the hydrolytic activity of ATP synthase when mitochondrial membrane potential (Δμ) falls, as in ischemia. Other roles have been ascribed to...
5.
Sgarbi G, Righetti R, Del Dotto V, Grillini S, Giorgio V, Baracca A, et al.
Biochim Biophys Acta Mol Basis Dis
. 2023 Sep;
1870(1):166879.
PMID: 37689158
The endogenous inhibitor of mitochondrial FF-ATPase (ATP synthase), IF, has been shown to exert pro-oncogenic actions, including reprogramming of cellular energy metabolism (Warburg effect). The latter action of IF has...
6.
Granata S, Canistro D, Vivarelli F, Morosini C, Rullo L, Mercatante D, et al.
Int J Mol Sci
. 2023 Aug;
24(15).
PMID: 37569836
The Food and Drug Administration has recently classified the IQOS electronic cigarette as a modified-risk tobacco product. However, IQOS cigarettes still release various harmful constituents typical of conventional cigarettes (CCs),...
7.
Chiariello A, Valente S, Pasquinelli G, Baracca A, Sgarbi G, Solaini G, et al.
Front Aging Neurosci
. 2023 Jan;
14:1058665.
PMID: 36698863
Introduction: Growth Differentiation Factor 15 (GDF15) is a mitochondrial-stress-responsive molecule whose expression strongly increases with aging and age-related diseases. However, its role in neurodegenerative diseases, including Alzheimer's disease (AD), is...
8.
Galber C, Fabbian S, Gatto C, Grandi M, Carissimi S, Acosta M, et al.
Cell Death Dis
. 2023 Jan;
14(1):54.
PMID: 36690622
The mitochondrial protein IF1 binds to the catalytic domain of the ATP synthase and inhibits ATP hydrolysis in ischemic tissues. Moreover, IF1 is overexpressed in many tumors and has been...
9.
Gatto C, Grandi M, Solaini G, Baracca A, Giorgio V
Front Physiol
. 2022 Aug;
13:917203.
PMID: 35991181
The endogenous inhibitor of ATP synthase is a protein of about 10 kDa, known as IF1 which binds to the catalytic domain of the enzyme during ATP hydrolysis. The main...
10.
Zheng X, Narayanan S, Xu C, Eliasson Angelstig S, Grunler J, Zhao A, et al.
Elife
. 2022 Feb;
11.
PMID: 35164902
Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development of diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role...