Gernot Wassmer
Overview
Explore the profile of Gernot Wassmer including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
448
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Recent Articles
1.
Schuurhuis S, Wassmer G, Kieser M, Pahlke F, Kunz C, Herrmann C
BMC Med Res Methodol
. 2024 Oct;
24(1):242.
PMID: 39420280
Background: In group-sequential designs, it is typically assumed that there is no time gap between patient enrollment and outcome measurement in clinical trials. However, in practice, there is usually a...
2.
Stallard N, Hampson L, Benda N, Brannath W, Burnett T, Friede T, et al.
Stat Biopharm Res
. 2021 Jun;
12(4):483-497.
PMID: 34191981
The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to...
3.
Jorgens S, Wassmer G, Konig F, Posch M
Pharm Stat
. 2019 Jan;
18(3):329-350.
PMID: 30652401
Adaptive trial methodology for multiarmed trials and enrichment designs has been extensively discussed in the past. A general principle to construct test procedures that control the family-wise Type I error...
4.
Friede T, Posch M, Zohar S, Alberti C, Benda N, Comets E, et al.
Orphanet J Rare Dis
. 2018 Oct;
13(1):186.
PMID: 30359266
Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This led to an...
5.
Graf A, Wassmer G, Friede T, Gera R, Posch M
Stat Methods Med Res
. 2018 Jun;
28(6):1879-1892.
PMID: 29888651
With the advent of personalized medicine, clinical trials studying treatment effects in subpopulations are receiving increasing attention. The objectives of such studies are, besides demonstrating a treatment effect in the...
6.
Bauer P, Bretz F, Dragalin V, Konig F, Wassmer G
Stat Med
. 2016 Jan;
35(3):364-7.
PMID: 26757956
No abstract available.
7.
Bauer P, Bretz F, Dragalin V, Konig F, Wassmer G
Stat Med
. 2015 Mar;
35(3):325-47.
PMID: 25778935
'Multistage testing with adaptive designs' was the title of an article by Peter Bauer that appeared 1989 in the German journal Biometrie und Informatik in Medizin und Biologie. The journal...
8.
Wassmer G, Dragalin V
J Biopharm Stat
. 2014 Jun;
25(4):651-69.
PMID: 24905739
Adaptive population enrichment designs enable the data-driven selection of one or more pre-specified subpopulations in an interim analysis, and the confirmatory proof of efficacy in the selected subset at the...
9.
Hunseler C, Balling G, Rohlig C, Blickheuser R, Trieschmann U, Lieser U, et al.
Pediatr Crit Care Med
. 2014 Apr;
15(6):511-22.
PMID: 24751788
Objectives: To assess the influence of an infusion of clonidine 1 μg/kg/hr on fentanyl and midazolam requirement in ventilated newborns and infants. Design: Prospective, double-blind, randomized controlled multicenter trial. Controlled...
10.
Liakopoulos O, Kuhn E, Slottosch I, Wassmer G, Wahlers T
Cochrane Database Syst Rev
. 2012 Apr;
(4):CD008493.
PMID: 22513959
Background: Patients referred to cardiac surgery for cardiovascular disease are at significant risk for the development of post-operative major adverse events despite significant advances in surgical techniques and perioperative care....