Gernot Bruchelt
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Explore the profile of Gernot Bruchelt including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
191
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Recent Articles
1.
Bruchelt G, Klose C, Lischka M, Brandes M, Handgretinger R, Brueckner R
J Clin Med
. 2023 Jul;
12(13).
PMID: 37445504
The therapy of neuroblastoma relies, amongst other things, on administering chemotherapeutics and radioactive compounds, e.g., the (-iodobenzyl)guanidine [I]mIBG. For special applications (conditioning before stem cell transplantation), busulfan and melphalan (M)...
2.
Bruchelt G, Treuner J, Schmidt K
Med Hypotheses
. 2022 Nov;
168:110969.
PMID: 36317071
Interferons (IFN), first described 1957 by Isaacs and Lindemann, are antiviral proteins generated in cells after viral infections. One of several interferon-induced effector mechanisms is the so called 2-5A /...
3.
Laugwitz L, Santhanakumaran V, Spieker M, Boehringer J, Bender B, Gieselmann V, et al.
JIMD Rep
. 2022 Jul;
63(4):292-302.
PMID: 35822086
Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease caused by deficiency of arylsulfatase A (ARSA). Heterozygous carriers of disease-causing variants and individuals harbouring pseudodeficiency alleles in the gene...
4.
Strobel S, Hesse N, Santhanakumaran V, Groeschel S, Bruchelt G, Krageloh-Mann I, et al.
Cells
. 2020 Dec;
9(12).
PMID: 33260765
(1) Lysosomal storage diseases are rare inherited disorders with no standardized or commercially available tests for biochemical diagnosis. We present factors influencing the quality of enzyme assays for metachromatic leukodystrophy...
5.
Iliev D, Braun R, Sanchez-Guijo A, Hartmann M, Wudy S, Heckmann D, et al.
Front Endocrinol (Lausanne)
. 2020 May;
11:240.
PMID: 32435230
An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS...
6.
Pajarola S, Weissenberg C, Baysal F, Bruchelt G, Krageloh-Mann I, Bohringer J
J Chromatogr B Analyt Technol Biomed Life Sci
. 2019 Jun;
1124:109-113.
PMID: 31195190
Metachromatic Leukodystrophy (MLD) and Multiple Sulfatase Deficiency (MSD) are rare and ultra-rare lysosomal storage diseases. Due to enzyme defects, patients are unable to split the sulfategroup from the respective substrates....
7.
Kuci Z, Ehrlichmann W, Sauer J, Handgretinger R, Bruchelt G, Reischl G
J Labelled Comp Radiopharm
. 2019 May;
62(8):438-447.
PMID: 31090094
The catecholamine analogue [ I]mIBG has been used for scintigraphic imaging of neuroblastoma since 1984. It is taken up by the noradrenaline transporter (NAT), which is present in most neuroblastoma...
8.
Krampen L, Krajewski S, Roth H, Handgretinger R, Schlensak C, Bruchelt G, et al.
Blood Transfus
. 2017 Feb;
16(4):343-347.
PMID: 28151392
No abstract available.
9.
Bayer M, Schmitt J, Dittmann H, Handgretinger R, Bruchelt G, Sauter A
Nucl Med Biol
. 2016 Jul;
43(9):543-551.
PMID: 27376201
Introduction: Radiolabeled meta-iodobenzylguanidine (mIBG) is used for imaging and therapy of neuroblastoma as well as pheochromocytoma. However, non-tumorous tissues also incorporate mIBG mainly by organic cation transporters (OCTs). In this...
10.
Cabanillas Stanchi K, Bruchelt G, Handgretinger R, Holzer U
Cancer Biol Ther
. 2015 Jul;
16(9):1353-63.
PMID: 26177922
Neuroblastoma is one of the most common solid tumors in childhood and usually accompanied with poor prognosis and rapid tumor progression when diagnosed with amplification of the proto-oncogene N-Myc. The...