Georgi Dimchev
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Explore the profile of Georgi Dimchev including associated specialties, affiliations and a list of published articles.
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11
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359
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Recent Articles
1.
Fassler F, Javoor M, Datler J, Doring H, Hofer F, Dimchev G, et al.
Sci Adv
. 2023 Jan;
9(3):eadd6495.
PMID: 36662867
Regulation of the Arp2/3 complex is required for productive nucleation of branched actin networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the Arp2/3 complex. Specifically,...
2.
Computational toolbox for ultrastructural quantitative analysis of filament networks in cryo-ET data
Dimchev G, Amiri B, Fassler F, Falcke M, Schur F
J Struct Biol
. 2021 Nov;
213(4):107808.
PMID: 34742832
A precise quantitative description of the ultrastructural characteristics underlying biological mechanisms is often key to their understanding. This is particularly true for dynamic extra- and intracellular filamentous assemblies, playing a...
3.
Morandell J, Schwarz L, Basilico B, Tasciyan S, Dimchev G, Nicolas A, et al.
Nat Commun
. 2021 May;
12(1):3058.
PMID: 34031387
De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 (CUL3) lead to autism spectrum disorder (ASD). In mouse, constitutive Cul3 haploinsufficiency leads to motor coordination deficits as...
4.
Dimchev V, Lahmann I, Koestler S, Kage F, Dimchev G, Steffen A, et al.
Front Cell Dev Biol
. 2021 Feb;
9:634708.
PMID: 33598464
The Arp2/3 complex generates branched actin filament networks operating in cell edge protrusion and vesicle trafficking. Here we employ a conditional knockout mouse model permitting tissue- or cell-type specific deletion...
5.
Fassler F, Dimchev G, Hodirnau V, Wan W, Schur F
Nat Commun
. 2020 Dec;
11(1):6437.
PMID: 33353942
The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly regulated and involves complex structural rearrangements and actin...
6.
Damiano-Guercio J, Kurzawa L, Mueller J, Dimchev G, Schaks M, Nemethova M, et al.
Elife
. 2020 May;
9.
PMID: 32391788
Cell migration entails networks and bundles of actin filaments termed lamellipodia and microspikes or filopodia, respectively, as well as focal adhesions, all of which recruit Ena/VASP family members hitherto thought...
7.
Dimchev G, Amiri B, Humphries A, Schaks M, Dimchev V, Stradal T, et al.
J Cell Sci
. 2020 Feb;
133(7).
PMID: 32094266
Efficient migration on adhesive surfaces involves the protrusion of lamellipodial actin networks and their subsequent stabilization by nascent adhesions. The actin-binding protein lamellipodin (Lpd) is thought to play a critical...
8.
Dimchev G, Rottner K
J Vis Exp
. 2018 May;
(135).
PMID: 29806847
Examining the spatiotemporal dynamics of proteins can reveal their functional importance in various contexts. In this article, it is discussed how fluorescent recovery after photobleaching (FRAP) and photoactivation techniques can...
9.
Dimchev G, Steffen A, Kage F, Dimchev V, Pernier J, Carlier M, et al.
Mol Biol Cell
. 2017 Mar;
28(10):1311-1325.
PMID: 28331069
Cell migration and cell-cell communication involve the protrusion of actin-rich cell surface projections such as lamellipodia and filopodia. Lamellipodia are networks of actin filaments generated and turned over by filament...
10.
Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, et al.
Nat Commun
. 2017 Mar;
8:14832.
PMID: 28327544
Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are...