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George W Huntley

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Recent Articles
1.
Guevara C, Alloo K, Gupta S, Thomas R, Del Valle P, Magee A, et al.
Front Behav Neurosci . 2024 Sep; 18:1445184. PMID: 39328984
Anxiety is a psychiatric non-motor symptom of Parkinson's that can appear in the prodromal period, prior to significant loss of midbrain dopamine neurons and motor symptoms. Parkinson's-related anxiety affects females...
2.
Gupta S, Tielemans A, Guevara C, Huntley G, Benson D
Proc Natl Acad Sci U S A . 2024 Jul; 121(28):e2317833121. PMID: 38968112
Parkinson's disease (PD) is a multifactorial disease that affects multiple brain systems and circuits. While defined by motor symptoms caused by degeneration of brainstem dopamine neurons, debilitating non-motor abnormalities in...
3.
Guevara C, Alloo K, Gupta S, Thomas R, Del Valle P, Magee A, et al.
bioRxiv . 2024 Jun; PMID: 38895277
Anxiety is a psychiatric non-motor symptom of Parkinson's that can appear in the prodromal period, prior to significant loss of brainstem dopamine neurons and motor symptoms. Parkinson's-related anxiety affects females...
4.
Gupta S, Guevara C, Tielemans A, Huntley G, Benson D
bioRxiv . 2023 Oct; PMID: 37905106
Significance Statement: Mutations in LRRK2 are common genetic risks for PD. mice fail to exhibit long-term potentiation at corticostriatal synapses and show significant deficits in frontal-striatal based cognitive tasks. While...
5.
Mesias R, Zaki Y, Guevara C, Friedman L, Hussein A, Therrien K, et al.
iScience . 2023 Oct; 26(10):108002. PMID: 37854688
Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the...
6.
Lin H, Cathomas F, Li L, Durand-de Cuttoli R, Guevara C, Sevim Bayrak C, et al.
bioRxiv . 2023 Sep; PMID: 37662400
Chronic stress induces changes in the periphery and the central nervous system (CNS) that contribute to neuropathology and behavioral abnormalities associated with psychiatric disorders. In this study, we examined the...
7.
Mesias R, Zaki Y, Guevara C, Friedman L, Hussein A, Therrien K, et al.
bioRxiv . 2023 Mar; PMID: 36993639
Rational decision making is grounded in learning to associate actions with outcomes, a process that depends on projections from prefrontal cortex to dorsomedial striatum. Symptoms associated with a variety of...
8.
Hussein A, Tielemans A, Baxter M, Benson D, Huntley G
Exp Neurol . 2022 Jun; 355:114145. PMID: 35732218
Impaired executive function is a common and debilitating non-motor symptom of idiopathic and hereditary Parkinson's disease (PD), but there is little understanding of the underlying pathophysiological mechanisms and circuits. The...
9.
de la Fuente Revenga M, Zhu B, Guevara C, Naler L, Saunders J, Zhou Z, et al.
Cell Rep . 2021 Oct; 37(3):109836. PMID: 34686347
Clinical evidence suggests that rapid and sustained antidepressant action can be attained with a single exposure to psychedelics. However, the biological substrates and key mediators of psychedelics' enduring action remain...
10.
Hussein A, Guevara C, Del Valle P, Gupta S, Benson D, Huntley G
Neuroscientist . 2021 May; 29(1):97-116. PMID: 33966533
Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well,...