George Ku
Overview
Explore the profile of George Ku including associated specialties, affiliations and a list of published articles.
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4
Citations
254
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Recent Articles
1.
Bernardino L, Balosso S, Ravizza T, Marchi N, Ku G, Randle J, et al.
J Neurochem
. 2008 Apr;
106(1):271-80.
PMID: 18384650
We investigated the consequences of transient application of specific stimuli mimicking inflammation to hippocampal tissue on microglia activation and neuronal cell vulnerability to a subsequent excitotoxic insult. Two-week-old organotypic hippocampal...
2.
Wannamaker W, Davies R, Namchuk M, Pollard J, Ford P, Ku G, et al.
J Pharmacol Exp Ther
. 2007 Feb;
321(2):509-16.
PMID: 17289835
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765) is an orally absorbed prodrug of (S)-3-({1-[(S)-1-((S)-2-{[1-(4-amino-3-chlorophenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidin-2yl]-methanoyl}-amino)-4-oxo-butyric acid (VRT-043198), a potent and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits 100- to 10,000-fold selectivity against...
3.
Ravizza T, Lucas S, Balosso S, Bernardino L, Ku G, Noe F, et al.
Epilepsia
. 2006 Aug;
47(7):1160-8.
PMID: 16886979
Purpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral administration of interleukin-1 (IL-1)-beta has proconvulsant effects, whereas its endogenous receptor...
4.
Garcia G, Xia Y, Ku G, Johnson R, Wilson C, Feng L
Kidney Int
. 2003 Jun;
64(1):160-9.
PMID: 12787406
Background: Interleukin-18 (IL-18), a potent inducer of interferon gamma (IFN-gamma) production, is a cytokine involved in the cell-mediated immune response that is expressed during inflammatory and pathologic conditions. IFN-gamma plays...