George J Cianciolo
Overview
Explore the profile of George J Cianciolo including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
122
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Recent Articles
1.
Ledford J, Goto H, Potts E, Degan S, Chu H, Voelker D, et al.
J Immunol
. 2015 Sep;
195(6):2917-8.
PMID: 26342104
No abstract available.
2.
Mo L, Pospichalova V, Huang Z, Murphy S, Payne S, Wang F, et al.
PLoS One
. 2015 Jul;
10(7):e0131579.
PMID: 26148191
Chemotherapy resistance is the major reason for the failure of ovarian cancer treatment. One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport...
3.
Cianciolo G, Pizzo S
PLoS One
. 2013 Jan;
7(12):e52693.
PMID: 23285152
Malignant and inflammatory tissues sometimes express endogenous retroviruses or their proteins. A highly-conserved sequence from retroviral transmembrane (TM) proteins, termed the "immunosuppressive domain (ID)", is associated with inhibition of immune...
4.
Angaswamy N, Fukami N, Tiriveedhi V, Cianciolo G, Mohanakumar T
Cell Transplant
. 2012 Apr;
21(6):1285-96.
PMID: 22469483
Inflammatory insults following islet transplantation (ITx) hinders engraftment and long-term function of the transplanted (Tx) islets. Using a murine model of ITx, we determined the role of LMP-420, a novel...
5.
Bowers E, Horvath J, Bond J, Cianciolo G, Pizzo S
J Leukoc Biol
. 2009 Aug;
86(5):1259-68.
PMID: 19652028
alpha(2)M* targets antigens to APCs for rapid internalization, processing, and presentation. When used as an antigen-delivery vehicle, alpha(2)M* amplifies MHC class II presentation, as demonstrated by increased antibody titers. Recent...
6.
Ledford J, Goto H, Potts E, Degan S, Chu H, Voelker D, et al.
J Immunol
. 2009 Jun;
182(12):7818-27.
PMID: 19494306
The lung is constantly challenged during normal breathing by a myriad of environmental irritants and infectious insults. Pulmonary host defense mechanisms maintain homeostasis between inhibition/clearance of pathogens and regulation of...
7.
Kaczowka S, Madding L, Epting K, Kelly R, Cianciolo G, Pizzo S
Int J Biol Macromol
. 2007 Nov;
42(1):62-7.
PMID: 17996290
alpha2-Macroglobulin (alpha2M) is a 718 kDa homotetrameric proteinase inhibitor which undergoes a large conformational change upon activation. This conformational change can occur either by proteolytic attack on an approximately 40...
8.
Anderson R, Cianciolo G, Kennedy M, Pizzo S
J Leukoc Biol
. 2007 Oct;
83(2):381-92.
PMID: 17967834
CpG oligodeoxynucleotides (ODN) stimulate the immune system and are under evaluation as treatments and vaccine adjuvants for infectious diseases, cancer, and immune system disorders. Although they have shown promising results...
9.
Incorporation of low molecular weight molecules into alpha(2)-macroglobulin by nucleophilic exchange
Bond J, Cianciolo G, Pizzo S
Biochem Biophys Res Commun
. 2007 Apr;
357(2):433-8.
PMID: 17428443
alpha(2)-Macroglobulin (alpha(2)M) is a proteinase inhibitor that functions by a trapping mechanism which has been exploited such that the receptor-recognized, activated form (alpha(2)M( *)) can be employed to target antigens...
10.
Wassmer S, Cianciolo G, Combes V, Grau G
Med Sci (Paris)
. 2006 Apr;
22(4):343-5.
PMID: 16597395
No abstract available.