George D Pins
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Explore the profile of George D Pins including associated specialties, affiliations and a list of published articles.
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36
Citations
594
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Recent Articles
1.
Lee H, Samolyk B, Pins G
J Funct Biomater
. 2025 Jan;
16(1).
PMID: 39852577
Large skeletal muscle injuries such as volumetric muscle loss (VML) disrupt native tissue structures, including biophysical and biochemical signaling cues that promote the regeneration of functional skeletal muscle. Various biofabrication...
2.
Carnes M, Gonyea C, Coburn J, Pins G
Explor Biomat X
. 2024 Jul;
1(2):58-83.
PMID: 39070763
Aim: The pleiotropic effect of fibroblast growth factor 2 (FGF2) on promoting myogenesis, angiogenesis, and innervation makes it an ideal growth factor for treating volumetric muscle loss (VML) injuries. While...
3.
Samolyk B, Pace Z, Li J, Billiar K, Coburn J, Whittington C, et al.
Tissue Eng Part C Methods
. 2024 Apr;
30(5):217-228.
PMID: 38562112
Functional regeneration of anisotropically aligned tissues such as ligaments, microvascular networks, myocardium, or skeletal muscle requires a temporal and spatial series of biochemical and biophysical cues to direct cell functions...
4.
English E, Samolyk B, Gaudette G, Pins G
J Biomed Mater Res A
. 2023 Mar;
111(9):1309-1321.
PMID: 36932841
Cardiovascular disease is the leading cause of death in the United States, which can result in blockage of a coronary artery, triggering a myocardial infarction (MI), scar tissue formation in...
5.
Chrobak M, Hansen K, Gershlak J, Vratsanos M, Kanellias M, Gaudette G, et al.
ACS Biomater Sci Eng
. 2021 Jan;
3(7):1394-1403.
PMID: 33429697
The ability to modulate the mechanical properties, and cell alignment within a cardiac patch without hindering cell functionality may have significant impact on developing therapies for treating myocardial infarctions. We...
6.
Carnes M, Pins G
Bioengineering (Basel)
. 2020 Aug;
7(3).
PMID: 32751847
Millions of Americans suffer from skeletal muscle injuries annually that can result in volumetric muscle loss (VML), where extensive musculoskeletal damage and tissue loss result in permanent functional deficits. In...
7.
Carnes M, Gonyea C, Mooney R, Njihia J, Coburn J, Pins G
Tissue Eng Part C Methods
. 2020 May;
26(6):317-331.
PMID: 32364015
Horseradish peroxidase (HRP) has been investigated as a catalyst to crosslink tissue-engineered hydrogels because of its mild reaction conditions and ability to modulate the mechanical properties of the matrix. Here,...
8.
Robbins E, Pins G, Laflamme M, Gaudette G
J Biomed Mater Res A
. 2020 Apr;
108(10):2123-2132.
PMID: 32323417
Myocardial infarction (MI) results in the death of cardiac tissue, decreases regional contraction, and can lead to heart failure. Tissue engineered cardiac patches containing human induced pluripotent stem cell-derived cardiomyocytes...
9.
Carnes M, Pins G
J Biomed Mater Res B Appl Biomater
. 2020 Jan;
108(5):2308-2319.
PMID: 31967415
To regenerate functional muscle tissue, engineered scaffolds should impart topographical features to induce myoblast alignment by a phenomenon known as contact guidance. Myoblast alignment is an essential step towards myotube...
10.
Shazeeb M, Howes S, Kandasamy S, Peiris T, Sotak C, Pins G
NMR Biomed
. 2019 Jan;
32(3):e4059.
PMID: 30657204
The in vivo evaluation of soft biomaterial implant remodeling routinely requires the surgical removal of the implant for subsequent histological assessment of tissue ingrowth and scaffold remodeling. This approach is...