George Carlson
Overview
Explore the profile of George Carlson including associated specialties, affiliations and a list of published articles.
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Articles
20
Citations
1089
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0
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Recent Articles
1.
Kim T, Lee I, Cho J, Canine B, Keller A, Price N, et al.
Mol Brain
. 2020 Jan;
13(1):10.
PMID: 31959236
Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present core transcriptional regulatory circuits underlying early...
2.
Park L, Uekawa K, Garcia-Bonilla L, Koizumi K, Murphy M, Pistik R, et al.
Circ Res
. 2017 May;
121(3):258-269.
PMID: 28515043
Rationale: Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia. The amyloid-β peptide (Aβ), a key pathogenic...
3.
Ament S, Pearl J, Grindeland A, St Claire J, Earls J, Kovalenko M, et al.
Hum Mol Genet
. 2017 Mar;
26(5):913-922.
PMID: 28334820
Huntington's disease is a dominantly inherited neurodegenerative disease caused by the expansion of a CAG repeat in the HTT gene. In addition to the length of the CAG expansion, factors...
4.
Pickett E, Henstridge C, Allison E, Pitstick R, Pooler A, Wegmann S, et al.
Synapse
. 2017 Feb;
71(6).
PMID: 28196395
Synaptic dysfunction and loss is the strongest pathological correlate of cognitive decline in Alzheimer's disease (AD) with increasing evidence implicating neuropathological tau protein in this process. Despite the knowledge that...
5.
Husson H, Moreno S, Smith L, Smith M, Russo R, Pitstick R, et al.
Hum Mol Genet
. 2016 Apr;
25(11):2245-2255.
PMID: 27053712
Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation of fluid-filled kidney cysts and progression to end-stage renal disease. A mechanistic understanding of cystogenesis is crucial...
6.
Ahn M, Kalume F, Pitstick R, Oehler A, Carlson G, DeArmond S
J Neuropathol Exp Neurol
. 2016 Feb;
75(3):256-62.
PMID: 26851378
Drug discovery for neurodegenerative diseases is particularly challenging because of the discrepancies in drug effects between in vitro and in vivo studies. These discrepancies occur in part because current cell...
7.
Anderson S, Lee I, Ebeling C, Stephenson D, Schweitzer K, Baxter D, et al.
Mamm Genome
. 2014 Nov;
26(1-2):80-93.
PMID: 25399070
Mice homozygous for the gray tremor (gt) mutation have a pleiotropic phenotype that includes pigmentation defects, megacolon, whole body tremors, sporadic seizures, hypo- and dys-myelination of the central nervous system...
8.
Helmering J, Juan T, Li C, Chhoa M, Baron W, Gyuris T, et al.
Lipids Health Dis
. 2014 Nov;
13:167.
PMID: 25361754
Background: Previously, we identified three loci affecting HDL-cholesterol levels in a screen for ENU-induced mutations in mice and discovered two mutated genes. We sought to identify the third mutated gene...
9.
Park L, Koizumi K, El Jamal S, Zhou P, Previti M, Van Nostrand W, et al.
Stroke
. 2014 May;
45(6):1815-21.
PMID: 24781082
Background And Purpose: Accumulation of amyloid-β in cerebral blood vessels occurs in familial and sporadic forms of cerebral amyloid angiopathy and is a prominent feature of Alzheimer disease. However, the...
10.
Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, et al.
FEBS Lett
. 2013 Oct;
587(22):3722-8.
PMID: 24113653
Aggregation of tau into paired helical filaments is a pathological process leading to neurotoxicity in Alzheimer's disease and other tauopathies. Tau is posttranslationally modified by O-linked N-acetylglucosamine (O-GlcNAc), and increasing...