George A Pantelopulos
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Explore the profile of George A Pantelopulos including associated specialties, affiliations and a list of published articles.
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21
Citations
221
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Recent Articles
1.
Pantelopulos G, Abraham C, Straub J
Annu Rev Biophys
. 2024 Feb;
53(1):455-486.
PMID: 38382114
Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease. We propose that...
2.
Abraham C, Xu L, Pantelopulos G, Straub J
Biophys J
. 2023 Sep;
122(19):3999-4010.
PMID: 37658602
The β-secretase, BACE1, and the α-secretase, ADAM10, are known to competitively cleave amyloid precursor protein (APP) in the amyloid cascades of Alzheimer's disease. Cleavage of APP by BACE1 produces a...
3.
Pantelopulos G, Matsuoka D, Hutchison J, Sanders C, Sugita Y, Straub J, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(52):e2212207119.
PMID: 36538482
The 99-residue C-terminal domain of amyloid precursor protein (APP-C99), precursor to amyloid beta (A), is a transmembrane (TM) protein containing intrinsically disordered N- and C-terminal extramembrane domains. Using molecular dynamics...
4.
Kwon S, Pantelopulos G, Straub J
Biophys J
. 2022 Aug;
122(11):1914-1925.
PMID: 35962549
An approach for the efficient simulation of phase-separated lipid bilayers, for use in the calculation of equilibrium free energies of partitioning between lipid domains, is proposed. The methodology exploits restraint...
5.
Harris J, Pantelopulos G, Straub J
J Phys Chem B
. 2021 May;
125(19):5068-5077.
PMID: 33961427
The spontaneous formation of micelles in aqueous solutions is governed by the amphipathic nature of surfactants and is practically interesting due to the regular use of micelles as membrane mimics,...
6.
Elkins M, Bandara A, Pantelopulos G, Straub J, Hong M
J Phys Chem B
. 2021 Feb;
125(7):1825-1837.
PMID: 33560844
Cholesterol is a ubiquitous component of mammalian cell membranes and affects membrane protein function. Although cholesterol-mediated formation of ordered membrane domains has been extensively studied, molecular-level structural information about cholesterol...
7.
Pantelopulos G, Panahi A, Straub J
J Phys Chem B
. 2020 Nov;
124(45):10173-10185.
PMID: 33135883
Elevated levels of cellular cholesterol have been identified as one factor contributing to the onset of Alzheimer's disease (AD). Specific interaction between cholesterol and the amyloid precursor protein (APP), investigated...
8.
Hutchison J, Shih K, Scheidt H, Fantin S, Parson K, Pantelopulos G, et al.
J Am Chem Soc
. 2020 Jun;
142(29):12715-12729.
PMID: 32575981
How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of isotropic model membrane systems that contain abundant sphingolipids...
9.
Bandara A, Panahi A, Pantelopulos G, Straub J
J Comput Chem
. 2019 Aug;
40(26):2348.
PMID: 31418884
No abstract available.
10.
Bandara A, Panahi A, Pantelopulos G, Nagai T, Straub J
J Chem Phys
. 2019 Jun;
150(20):204702.
PMID: 31153187
The separation of lipid mixtures into thermodynamically stable phase-separated domains is dependent on lipid composition, temperature, and system size. Using molecular dynamics simulations, the line tension between thermodynamically stable lipid...