Georg Tascher
Overview
Explore the profile of Georg Tascher including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
1146
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Recent Articles
1.
Sanz-Martinez P, Tascher G, Cano-Franco S, Cabrerizo-Poveda P, Munch C, Homan E, et al.
J Mol Biol
. 2024 Jun;
436(15):168643.
PMID: 38848865
Autophagy facilitates the degradation of cellular content via the lysosome and is involved in cellular homeostasis and stress response pathways. As such, malfunction of autophagy is linked to a variety...
2.
Berkane R, Ho-Xuan H, Glogger M, Sanz-Martinez P, Brunello L, Glaesner T, et al.
Nat Commun
. 2023 Dec;
14(1):8364.
PMID: 38102139
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes. We recently showed that...
3.
Donig J, Mende H, Davila Gallesio J, Wagner K, Hotz P, Schunck K, et al.
Nat Commun
. 2023 Dec;
14(1):8121.
PMID: 38065954
Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes. Ribosome biogenesis is tightly...
4.
Mende H, Khatri A, Lange C, Poveda-Cuevas S, Tascher G, Covarrubias-Pinto A, et al.
Cell Rep
. 2023 Nov;
42(12):113484.
PMID: 37999976
The nucleolar scaffold protein NPM1 is a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants promoting its aberrant cytoplasmic localization, are the...
5.
Reisbeck L, Linder B, Tascher G, Bozkurt S, Weber K, Herold-Mende C, et al.
Am J Physiol Cell Physiol
. 2023 Oct;
325(6):C1451-C1469.
PMID: 37899749
Induction of alternative, non-apoptotic cell death programs such as cell-lethal autophagy and mitophagy represent possible strategies to combat glioblastoma (GBM). Here we report that VLX600, a novel iron chelator and...
6.
Pereira R, Kumar R, Cais A, Paulini L, Kahler A, Bravo J, et al.
Nat Commun
. 2023 Oct;
14(1):6242.
PMID: 37802982
Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a...
7.
Sutandy F, Gossner I, Tascher G, Munch C
Nature
. 2023 Jun;
618(7966):849-854.
PMID: 37286597
The mitochondrial unfolded protein response (UPR) is essential to safeguard mitochondria from proteotoxic damage by activating a dedicated transcriptional response in the nucleus to restore proteostasis. Yet, it remains unclear...
8.
Metzler M, Tharyan R, Klann K, Grikscheit K, Bojkova D, Cinatl J, et al.
Mol Cell Proteomics
. 2023 Mar;
22(5):100537.
PMID: 37001587
The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies....
9.
Sanchez-Martin P, Kriegenburg F, Alves L, Adam J, Elsaesser J, Babic R, et al.
J Cell Sci
. 2023 Jan;
136(3).
PMID: 36644903
Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly formed double-membrane structure called the autophagosome, and subsequently targeted for degradation in the lytic compartment of...
10.
Hertel A, Alves L, Dutz H, Tascher G, Bonn F, Kaulich M, et al.
Cell Rep
. 2022 Dec;
41(10):111653.
PMID: 36476874
The endosomal-lysosomal system is a series of organelles in the endocytic pathway that executes trafficking and degradation of proteins and lipids and mediates the internalization of nutrients and growth factors...