Georg A Sprenger
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Explore the profile of Georg A Sprenger including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Palanisamy N, Degen A, Morath A, Ballestin J, Juraske C, Ozturk M, et al.
Nat Commun
. 2019 Nov;
10(1):4967.
PMID: 31672972
To build or dissect complex pathways in bacteria and mammalian cells, it is often necessary to recur to at least two plasmids, for instance harboring orthogonal inducible promoters. Here we...
12.
Trondle J, Schoppel K, Bleidt A, Trachtmann N, Sprenger G, Weuster-Botz D
J Biotechnol
. 2019 Oct;
307:15-28.
PMID: 31639341
E. coli strain NT1259 /pF112aroFBL was able to produce 14.3 g L L-tryptophan within 68 h in a fed-batch process from glycerol on a 15 L scale. To gain detailed...
13.
Sanchez-Moreno I, Trachtmann N, Ilhan S, Helaine V, Lemaire M, Guerard-Helaine C, et al.
Molecules
. 2019 Jul;
24(13).
PMID: 31261738
We have cloned, overexpressed, purified, and characterized a 2-ketogluconate kinase (2-dehydrogluconokinase, EC 2.7.1.13) from H16. Exploration of its substrate specificity revealed that three ketoacids (2-keto-3-deoxy-d-gluconate, 2-keto-d-gulonate, and 2-keto-3-deoxy-d-gulonate) with structures...
14.
Fries A, Mazzaferro L, Gruning B, Bisel P, Stibal K, Buchholz P, et al.
Chembiochem
. 2019 Mar;
20(13):1672-1677.
PMID: 30866142
Chorismate and isochorismate constitute branch-point intermediates in the biosynthesis of many aromatic metabolites in microorganisms and plants. To obtain unnatural compounds, we modified the route to menaquinone in Escherichia coli....
15.
Mohammadi Nargesi B, Sprenger G, Youn J
Front Bioeng Biotechnol
. 2019 Jan;
6:201.
PMID: 30662895
Aromatic amines are an important class of chemicals which are used as building blocks for the synthesis of polymers and pharmaceuticals. In this study we establish a pathway for the...
16.
Mohammadi Nargesi B, Trachtmann N, Sprenger G, Youn J
Microb Cell Fact
. 2018 Sep;
17(1):149.
PMID: 30241531
Background: The non-proteinogenic aromatic amino acid, p-amino-L-phenylalanine (L-PAPA) is a high-value product with a broad field of applications. In nature, L-PAPA occurs as an intermediate of the chloramphenicol biosynthesis pathway...
17.
Trondle J, Trachtmann N, Sprenger G, Weuster-Botz D
Biotechnol Bioeng
. 2018 Sep;
115(12):2881-2892.
PMID: 30199091
l-tryptophan is an essential amino acid of high industrial interest that is routinely produced by microbial processes from glucose as carbon source. Glycerol is an alternative substrate providing a variety...
18.
Schapfl M, Baier S, Fries A, Ferlaino S, Waltzer S, Muller M, et al.
Appl Microbiol Biotechnol
. 2018 Aug;
102(19):8359-8372.
PMID: 30062480
Carboligations catalyzed by aldolases or thiamine diphosphate (ThDP)-dependent enzymes are well-known in biocatalysis to deliver enantioselective chain elongation reactions. A pyruvate-dependent aldolase (2-oxo-3-deoxy-6-phosphogluconate aldolase [EDA]) introduces a chiral center when...
19.
Franke D, Sprenger G, Muller M
Angew Chem Int Ed Engl
. 2018 May;
40(3):555-557.
PMID: 29712027
As valuable chiral building blocks for the syntheses of natural products and pharmacologically active substances, especially of carbohydrate mimetics, functionalized cyclohexadiene-trans-diols such as (2S,3S)-dihydroxy-2,3-dihydrobenzoic acid (1) can be prepared easily...
20.
Trondle J, Albermann C, Weiner M, Sprenger G, Weuster-Botz D
Biotechnol J
. 2017 Dec;
13(5):e1700611.
PMID: 29220111
Usually perturbation of the metabolism of cells by addition of substrates is applied for metabolic analysis of production organisms, but perturbation studies are restricted to the endogenous substrates of the...