Geoffrey L Stephens
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Explore the profile of Geoffrey L Stephens including associated specialties, affiliations and a list of published articles.
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15
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1010
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Recent Articles
11.
Shevach E, Dipaolo R, Andersson J, Zhao D, Stephens G, Thornton A
Immunol Rev
. 2006 Aug;
212:60-73.
PMID: 16903906
Numerous studies over the past 10 years have demonstrated the importance of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells (nTregs) in immune regulation. We analyzed the mechanism of action...
12.
Shevach E, Stephens G
Nat Rev Immunol
. 2006 Jul;
6(8):613-8.
PMID: 16868552
Stimulation of T cells through GITR (glucocorticoid-induced tumour-necrosis-factor-receptor-related protein) has been shown to enhance immunity to tumours and viral pathogens, and to exacerbate autoimmune disease. The effects of stimulation through...
13.
Stephens G, McHugh R, Whitters M, Young D, Luxenberg D, Carreno B, et al.
J Immunol
. 2004 Oct;
173(8):5008-20.
PMID: 15470044
Nonactivated CD4+CD25+ regulatory T cells constitutively express glucocorticoid-induced TNFR family-related receptor (GITR), a TNFR family member whose engagement was presumed to abrogate regulatory T cell-mediated suppression. Using GITR-/- mice, we...
14.
Stephens G, Ignatowicz L
Eur J Immunol
. 2003 May;
33(5):1282-91.
PMID: 12731053
Thymus-derived CD4(+)CD25(+) regulatory T (T(r)) cells play a critical role in suppressing aberrant responses to self in vivo. The factors that influence a CD4(+) T cell's decision to commit to...
15.
Stephens G, Ashwell J, Ignatowicz L
Int Immunol
. 2003 Apr;
15(5):623-32.
PMID: 12697662
The sensitivity of T cells to agonist-induced death during development contrasts with their proliferative responses after agonist challenge in the periphery. The means by which TCR engagement results in these...