Geoffrey I Johnston
Overview
Explore the profile of Geoffrey I Johnston including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
319
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Recent Articles
1.
Hickford E, OConnell J, Maloney A, Florian P, Johnston G, Rospo C, et al.
Bioanalysis
. 2023 Apr;
15(6):343-359.
PMID: 37026566
An antibody specific to small-molecule inhibitor-bound TNF has enabled the development of target occupancy biomarker assays to support the development of novel treatments for autoimmune disorders. ELISAs were developed for...
2.
Diaz N, Juarez M, Cancrini C, Heeg M, Soler-Palacin P, Payne A, et al.
J Immunol
. 2020 Oct;
205(11):2979-2987.
PMID: 33115853
Mutations in two genes can result in activated PI3Kδ syndrome (APDS), a rare immunodeficiency disease with limited therapeutic options. Seletalisib, a potent, selective PI3Kδ inhibitor, was evaluated in patients with...
3.
Juarez M, Diaz N, Johnston G, Nayar S, Payne A, Helmer E, et al.
Rheumatology (Oxford)
. 2020 Sep;
60(3):1364-1375.
PMID: 32949140
Objectives: This phase 2 proof-of-concept study (NCT02610543) assessed efficacy, safety and effects on salivary gland inflammation of seletalisib, a potent and selective PI3Kδ inhibitor, in patients with moderate-to-severe primary Sjögren's...
4.
Smith A, Depp C, Ryan B, Johnston G, Alegre-Abarrategui J, Evetts S, et al.
Mov Disord
. 2018 Oct;
33(10):1580-1590.
PMID: 30294923
Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear...
5.
Chamberlain C, Colman P, Ranger A, Burkly L, Johnston G, Otoul C, et al.
Ann Rheum Dis
. 2017 Aug;
76(11):1837-1844.
PMID: 28780512
Objectives: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease associated with diffuse immune cell dysfunction. CD40-CD40 ligand (CD40L) interaction activates B cells, antigen-presenting cells and platelets. CD40L blockade might...
6.
Reynolds J, Paciga S, Sanders F, Hyde C, Loomis A, Johnston G
PLoS One
. 2012 Jan;
7(1):e29983.
PMID: 22253847
Several SNPs located in or around the IL28B gene are associated with response of patients infected with Hepatitis C virus to treatment with pegylated interferon-α ⁺/⁻ ribavirin or with spontaneous...
7.
Williamson R, Price J, Glancy S, Perry E, Nee L, Hayes P, et al.
Diabetes Care
. 2011 Apr;
34(5):1139-44.
PMID: 21478462
Objective: Type 2 diabetes is an established risk factor for development of hepatic steatosis and nonalcoholic fatty liver disease (NAFLD). We aimed to determine the prevalence and clinical correlates of...
8.
Zamparini A, Watts T, Gardner C, Tomlinson S, Johnston G, Brickman J
Development
. 2006 Aug;
133(18):3709-22.
PMID: 16936074
In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGFbeta. There are also a number of transcription factors that feedback upon these...