Geetha Srikrishna
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Explore the profile of Geetha Srikrishna including associated specialties, affiliations and a list of published articles.
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1515
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Recent Articles
1.
Srikrishna G, Bullen C, Bishai W
J Infect Dis Ther
. 2024 May;
12(2).
PMID: 38745994
No abstract available.
2.
Um P, Praharaj M, Lombardo K, Yoshida T, Matoso A, Baras A, et al.
bioRxiv
. 2024 Jan;
PMID: 38168333
Despite the introduction of several new agents for the treatment of bladder cancer (BC), intravesical BCG remains a first line agent for the management of non-muscle invasive bladder cancer. In...
3.
Rohilla A, Singh A, Koleske B, Srikrishna G, Bishai W
Microbiol Spectr
. 2023 Dec;
12(1):e0201223.
PMID: 38095464
In this paper, we describe novel inhibitors of cyclic dinucleotide phosphodiesterase enzymes from () (CdnP) and mammals (ENPP1). The phosphodiesterase enzymes hydrolyze cyclic dinucleotides, such as 2',3'-cyclic GMP-AMP and c-di-AMP,...
4.
Krug S, Gupta M, Kumar P, Feller L, Ihms E, Kang B, et al.
Nat Commun
. 2023 Dec;
14(1):8161.
PMID: 38071218
The antibiotic pyrazinamide (PZA) is a cornerstone of tuberculosis (TB) therapy that shortens treatment durations by several months despite being only weakly bactericidal. Intriguingly, PZA is also an anti-inflammatory molecule...
5.
Bullen C, Singh A, Krug S, Lun S, Thakur P, Srikrishna G, et al.
JCI Insight
. 2023 Sep;
8(20.
PMID: 37725440
Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I-like receptor (RLR) family perturbs innate immune control within macrophages; however, a distinct role of MDA5, a member of...
6.
Singh A, Wang R, Lombardo K, Praharaj M, Bullen C, Um P, et al.
iScience
. 2023 Sep;
26(10):107733.
PMID: 37674985
Bacillus Calmette-Guérin (BCG) confers heterologous immune protection against viral infections and has been proposed as vaccine against SARS-CoV-2 (SCV2). Here, we tested intravenous BCG vaccination against COVID-19 using the golden...
7.
Krug S, Prasad P, Xiao S, Lun S, Ruiz-Bedoya C, Klunk M, et al.
mBio
. 2023 Feb;
14(2):e0349622.
PMID: 36853048
Despite numerous advances in tuberculosis (TB) drug development, long treatment durations have led to the emergence of multidrug resistance, which poses a major hurdle to global TB control. Shortening treatment...
8.
Gupta M, Srikrishna G, Klein S, Bishai W
Trends Immunol
. 2022 Jul;
43(8):640-656.
PMID: 35842266
Tuberculosis (TB), the world's deadliest bacterial infection, afflicts more human males than females, with a male/female (M/F) ratio of 1.7. Sex disparities in TB prevalence, pathophysiology, and clinical manifestations are...
9.
Singh A, Praharaj M, Lombardo K, Yoshida T, Matoso A, Baras A, et al.
Nat Commun
. 2022 Feb;
13(1):878.
PMID: 35169141
In addition to its role as a TB vaccine, BCG has been shown to elicit heterologous protection against many other pathogens including viruses through a process termed trained immunity. Despite...
10.
Singh A, Srikrishna G, Bivalacqua T, Bishai W
Vaccine
. 2021 Oct;
39(50):7321-7331.
PMID: 34593271
Bacillus Calmette-Guérin (BCG) vaccine is an attenuated live strain of Mycobacterium bovis. It may be the most widely used vaccine in human history and is the only licensed human tuberculosis...