Geertrui Denecker
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Explore the profile of Geertrui Denecker including associated specialties, affiliations and a list of published articles.
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36
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1184
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Recent Articles
21.
De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, et al.
Mol Cell Biol
. 2010 Sep;
30(22):5394-405.
PMID: 20855528
Mdm2 and Mdm4 are critical negative regulators of p53. A large body of evidence indicates that elevated expression of either Mdm2 or Mdm4 may favor tumor formation by inhibiting p53...
22.
Sotiropoulou P, Candi A, Mascre G, De Clercq S, Youssef K, Lapouge G, et al.
Nat Cell Biol
. 2010 May;
12(6):572-82.
PMID: 20473297
Adult stem cells (SCs) are at high risk of accumulating deleterious mutations because they reside and self-renew in adult tissues for extended periods. Little is known about how adult SCs...
23.
Roelandt T, Giddelo C, Heughebaert C, Denecker G, Hupe M, Crumrine D, et al.
J Invest Dermatol
. 2008 Nov;
129(4):927-36.
PMID: 19005485
Epidermal permeability barrier formation depends upon lamellar body (LB) secretion/fusion with the apical plasma membrane (APM) of outermost stratum granulosum (SG) cell, creating cholesterol/glycosphingolipid-enriched lipid rafts-like domains. We found that...
24.
Denecker G, Ovaere P, Vandenabeele P, Declercq W
J Cell Biol
. 2008 Feb;
180(3):451-8.
PMID: 18250198
Caspase-14 is a unique member of the evolutionarily conserved family of cysteinyl aspartate-specific proteinases, which are mainly involved in inflammation and apoptosis. However, recent evidence also implicates these proteases in...
25.
Demerjian M, Hachem J, Tschachler E, Denecker G, Declercq W, Vandenabeele P, et al.
Am J Pathol
. 2007 Dec;
172(1):86-97.
PMID: 18156206
Stratum corneum comprises corneocytes, derived from outer stratum granulosum during terminal differentiation, embedded in a lipid-enriched extracellular matrix, secreted from epidermal lamellar bodies. Permeability barrier insults stimulate rapid secretion of...
26.
Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation
Sklyarova T, Bonne S, Dhooge P, Denecker G, Goossens S, De Rycke R, et al.
J Invest Dermatol
. 2007 Dec;
128(6):1375-85.
PMID: 18079750
We generated mice deficient in plakophilin-3 (PKP3), a member of the Armadillo-repeat family and a component of desmosomes and stress granules in epithelial cells. In these mice, several subsets of...
27.
Denecker G, Hoste E, Gilbert B, Hochepied T, Ovaere P, Lippens S, et al.
Nat Cell Biol
. 2007 May;
9(6):666-74.
PMID: 17515931
Caspase-14 belongs to a conserved family of aspartate-specific proteinases. Its expression is restricted almost exclusively to the suprabasal layers of the epidermis and the hair follicles. Moreover, the proteolytic activation...
28.
Vanden Berghe T, Kalai M, Denecker G, Meeus A, Saelens X, Vandenabeele P
Cell Signal
. 2005 Jul;
18(3):328-35.
PMID: 16023831
Due to loss of cell membrane integrity, necrotic cells passively release several cytosolic factors that can activate antigen presenting cells and other immune cells. In contrast, cells dying by apoptosis...
29.
Lamkanfi M, DHondt K, Vande Walle L, van Gurp M, Denecker G, Demeulemeester J, et al.
J Biol Chem
. 2004 Dec;
280(8):6923-32.
PMID: 15590671
The enzymatic activity of caspases is implicated in the execution of apoptosis and inflammation. Here we demonstrate a novel nonenzymatic function for caspase-2 other than its reported proteolytic role in...
30.
Lamkanfi M, Denecker G, Kalai M, DHondt K, Meeus A, Declercq W, et al.
J Biol Chem
. 2004 Sep;
279(50):51729-38.
PMID: 15383541
Using in silico methods for screening the human genome for new caspase recruitment domain (CARD) proteins, we have identified INCA (Inhibitory CARD) as a protein that shares 81% identity with...