Geertrui Denecker
Overview
Explore the profile of Geertrui Denecker including associated specialties, affiliations and a list of published articles.
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36
Citations
1184
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Recent Articles
11.
Decaesteker B, Denecker G, Van Neste C, Dolman E, Van Loocke W, Gartlgruber M, et al.
Nat Commun
. 2018 Nov;
9(1):4866.
PMID: 30451831
Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and...
12.
Mus L, Denecker G, Speleman F, Roman B
PLoS One
. 2018 Feb;
13(2):e0192548.
PMID: 29470507
Effective inhibitors of invasion and metastasis represent a serious unmet clinical need. We have recently identified 4-fluoro-3',4',5'-trimethoxychalcone or C16 as a potent anti-invasive molecule. In this paper, we report on...
13.
Claeys S, Denecker G, Cannoodt R, Kumps C, Durinck K, Speleman F, et al.
Oncotarget
. 2018 Jan;
8(63):106820-106832.
PMID: 29290991
Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies. The...
14.
Desmyter A, Spinelli S, Boutton C, Saunders M, Blachetot C, de Haard H, et al.
Front Immunol
. 2017 Sep;
8:884.
PMID: 28871249
The heterodimeric cytokine interleukin (IL) 23 comprises the IL12-shared p40 subunit and an IL23-specific subunit, p19. Together with IL12 and IL27, IL23 sits at the apex of the regulatory mechanisms...
15.
Devos M, Gilbert B, Denecker G, Leurs K, Mc Guire C, Lemeire K, et al.
J Invest Dermatol
. 2016 Oct;
137(2):494-505.
PMID: 27725202
Unlike its family member p53, TP63 is rarely mutated in human cancer. However, ΔNp63α protein levels are often elevated in tumors of epithelial origin, such as squamous cell carcinoma and...
16.
Quimbaya M, Raspe E, Denecker G, De Craene B, Roelandt R, Declercq W, et al.
Neoplasia
. 2014 Sep;
16(9):694-709.
PMID: 25246271
Genetic instability has emerged as an important hallmark of human neoplasia. Although most types of cancers exhibit genetic instability to some extent, in colorectal cancers genetic instability is a distinctive...
17.
Beck I, Drebert Z, Hoya-Arias R, Bahar A, Devos M, Clarisse D, et al.
PLoS One
. 2013 Aug;
8(7):e69115.
PMID: 23935933
Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger...
18.
Hoste E, Denecker G, Gilbert B, Van Nieuwerburgh F, van der Fits L, Asselbergh B, et al.
J Invest Dermatol
. 2012 Sep;
133(3):742-750.
PMID: 23014340
Caspase-14 is an important protease in the proper formation of a fully functional skin barrier. Newborn mice that are deficient in caspase-14 exhibit increased transepidermal water loss and are highly...
19.
Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, et al.
J Invest Dermatol
. 2011 Jun;
131(11):2233-41.
PMID: 21654840
Caspase-14 is a protease that is mainly expressed in suprabasal epidermal layers and activated during keratinocyte cornification. Caspase-14-deficient mice display reduced epidermal barrier function and increased sensitivity to UVB radiation....
20.
Migliorini D, Bogaerts S, Defever D, Vyas R, Denecker G, Radaelli E, et al.
J Clin Invest
. 2011 Mar;
121(4):1329-43.
PMID: 21403399
Biochemical studies have suggested conflicting roles for the E3 ubiquitin ligase constitutive photomorphogenesis protein 1 (Cop1; also known as Rfwd2) in tumorigenesis, providing evidence for both the oncoprotein c-Jun and...