Geert Trooskens
Overview
Explore the profile of Geert Trooskens including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
693
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0
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Recent Articles
1.
Haese A, Trooskens G, Steyaert S, Hessels D, Brawer M, Vlaeminck-Guillem V, et al.
J Urol
. 2019 Apr;
202(2):256-263.
PMID: 31026217
Purpose: A 2-gene, urine based molecular test that combines mRNA biomarkers with clinical factors can risk stratify patients for clinically significant prostate cancer. To ensure the generalizability of assay results...
2.
Coussement L, Bolca S, Van Criekinge W, Trooskens G, Mensaert K, Poels K, et al.
Sci Rep
. 2018 Sep;
8(1):13617.
PMID: 30206342
Upon soy consumption, isoflavone metabolites attain bioactive concentrations in breast tissue possibly affecting health. Though in vitro epigenetic activity of soy metabolites has been described, the in vivo impact on...
3.
Bosch L, Trooskens G, Snaebjornsson P, Coupe V, Mongera S, Haan J, et al.
Oncotarget
. 2017 Oct;
8(38):63140-63154.
PMID: 28968978
Diversity in colorectal cancer biology is associated with variable responses to standard chemotherapy. We aimed to identify and validate DNA hypermethylated genes as predictive biomarkers for irinotecan treatment of metastatic...
4.
Verlaat W, Snijders P, Novianti P, Wilting S, De Strooper L, Trooskens G, et al.
Clin Cancer Res
. 2017 Jan;
23(14):3813-3822.
PMID: 28119363
Epigenetic host cell changes involved in cervical cancer development following a persistent high-risk human papillomavirus (hrHPV) infection, provide promising markers for the management of hrHPV-positive women. In particular, markers based...
5.
Bosch L, Luo Y, Lao V, Snaebjornsson P, Trooskens G, Vlassenbroeck I, et al.
Clin Cancer Res
. 2016 Apr;
22(18):4612-22.
PMID: 27121793
Purpose: WRN promoter CpG island hypermethylation in colorectal cancer has been reported to increase sensitivity to irinotecan-based therapies. We aimed to characterize methylation of the WRN promoter, determine the effect...
6.
Van Neste L, Hendriks R, Dijkstra S, Trooskens G, Cornel E, Jannink S, et al.
Eur Urol
. 2016 Apr;
70(5):740-748.
PMID: 27108162
Background: To reduce overdiagnosis and overtreatment, a test is urgently needed to detect clinically significant prostate cancer (PCa). Objective: To develop a multimodal model, incorporating previously identified messenger RNA (mRNA)...
7.
Stewart G, Powles T, Van Neste C, Meynert A, OMahony F, Laird A, et al.
Oncotarget
. 2016 Mar;
7(18):25241-50.
PMID: 27029034
Background: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following targeted therapy...
8.
Trivedi M, Hodgson N, Walker S, Trooskens G, Nair V, Deth R
Nutr Metab (Lond)
. 2015 Dec;
12:54.
PMID: 26664459
Background: Casein-free, gluten-free diets have been reported to mitigate some of the inflammatory gastrointestinal and behavioral traits associated with autism, but the mechanism for this palliative effect has not been...
9.
De Meyer T, Bady P, Trooskens G, Kurscheid S, Bloch J, Kros J, et al.
Sci Rep
. 2015 Oct;
5:15375.
PMID: 26482909
Two cost-efficient genome-scale methodologies to assess DNA-methylation are MethylCap-seq and Illumina's Infinium HumanMethylation450 BeadChips (HM450). Objective information regarding the best-suited methodology for a specific research question is scant. Therefore, we...
10.
Noehammer C, Pulverer W, Hassler M, Hofner M, Wielscher M, Vierlinger K, et al.
Epigenomics
. 2014 Dec;
6(6):603-22.
PMID: 25531255
DNA methylation is a stable covalent epigenetic modification of primarily CpG dinucleotides that has recently gained considerable attention for its use as a biomarker in different clinical settings, including disease...