Gavin J McDonald
Overview
Explore the profile of Gavin J McDonald including associated specialties, affiliations and a list of published articles.
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10
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2929
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Recent Articles
1.
Deo R, Patterson N, Tandon A, McDonald G, Haiman C, Ardlie K, et al.
PLoS Genet
. 2007 Nov;
3(11):e196.
PMID: 18020707
Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results...
2.
Price A, Patterson N, Yu F, Cox D, Waliszewska A, McDonald G, et al.
Am J Hum Genet
. 2007 May;
80(6):1024-36.
PMID: 17503322
Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise...
3.
Haiman C, Patterson N, Freedman M, Myers S, Pike M, Waliszewska A, et al.
Nat Genet
. 2007 Apr;
39(5):638-44.
PMID: 17401364
After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer...
4.
Reich D, Patterson N, Ramesh V, De Jager P, McDonald G, Tandon A, et al.
Am J Hum Genet
. 2007 Mar;
80(4):716-26.
PMID: 17357077
Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from...
5.
Freedman M, Haiman C, Patterson N, McDonald G, Tandon A, Waliszewska A, et al.
Proc Natl Acad Sci U S A
. 2006 Sep;
103(38):14068-73.
PMID: 16945910
A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]....
6.
Reich D, Patterson N, De Jager P, McDonald G, Waliszewska A, Tandon A, et al.
Nat Genet
. 2005 Sep;
37(10):1113-8.
PMID: 16186815
Multiple sclerosis is a common disease with proven heritability, but, despite large-scale attempts, no underlying risk genes have been identified. Traditional linkage scans have so far identified only one risk...
7.
Winckler W, Myers S, Richter D, Onofrio R, McDonald G, Bontrop R, et al.
Science
. 2005 Feb;
308(5718):107-11.
PMID: 15705809
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both...
8.
Smith M, Patterson N, Lautenberger J, Truelove A, McDonald G, Waliszewska A, et al.
Am J Hum Genet
. 2004 Apr;
74(5):1001-13.
PMID: 15088270
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with...
9.
Freedman M, Reich D, Penney K, McDonald G, Mignault A, Patterson N, et al.
Nat Genet
. 2004 Mar;
36(4):388-93.
PMID: 15052270
Population stratification refers to differences in allele frequencies between cases and controls due to systematic differences in ancestry rather than association of genes with disease. It has been proposed that...
10.
Sabeti P, Reich D, Higgins J, Levine H, Richter D, Schaffner S, et al.
Nature
. 2002 Oct;
419(6909):832-7.
PMID: 12397357
The ability to detect recent natural selection in the human population would have profound implications for the study of human history and for medicine. Here, we introduce a framework for...