Gautham V Sridharan
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Explore the profile of Gautham V Sridharan including associated specialties, affiliations and a list of published articles.
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12
Citations
720
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Recent Articles
1.
Keibler M, Sridharan G, Sweetser M, Ticau S
JIMD Rep
. 2024 Jul;
65(4):262-271.
PMID: 38974609
Givosiran is a subcutaneously administered, liver-targeted RNA interference (RNAi) therapeutic that has been approved for treating acute hepatic porphyria (AHP). Elevation in plasma homocysteine (hyperhomocysteinemia) has been reported in AHP...
2.
Ticau S, Sridharan G, Tsour S, Cantley W, Chan A, Gilbert J, et al.
Neurology
. 2020 Oct;
96(3):e412-e422.
PMID: 33087494
Objective: To identify changes in the proteome associated with onset and progression of hereditary transthyretin-mediated (hATTR) amyloidosis, also known as ATTRv amyloidosis, we performed an observational, case-controlled study that compared...
3.
Krishnan S, Ding Y, Saeidi N, Choi M, Sridharan G, Sherr D, et al.
Cell Rep
. 2019 Sep;
28(12):3285.
PMID: 31533048
No abstract available.
4.
A novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion
Avruch J, Bruinsma B, Weeder P, Sridharan G, Porte R, Yeh H, et al.
Technology (Singap World Sci)
. 2019 May;
5(4):196-200.
PMID: 31106253
Machine perfusion-based organ preservation techniques are prudently transitioning into clinical practice. Although experimental data is compelling, the outcomes in the highly variable clinical donation-transplantation setting are unpredictable. Here, we offer...
5.
Krishnan S, Ding Y, Saedi N, Choi M, Sridharan G, Sherr D, et al.
Cell Rep
. 2018 Apr;
23(4):1099-1111.
PMID: 29694888
The gut microbiota plays a significant role in the progression of fatty liver disease; however, the mediators and their mechanisms remain to be elucidated. Comparing metabolite profile differences between germ-free...
6.
Bruinsma B, Avruch J, Sridharan G, Weeder P, Jacobs M, Crisalli K, et al.
Transplantation
. 2017 Feb;
101(7):1637-1644.
PMID: 28230641
Background: The ongoing shortage of donor livers for transplantation and the increased use of marginal livers necessitate the development of accurate pretransplant tests of viability. Considering the importance energy status...
7.
Bruinsma B, Sridharan G, Weeder P, Avruch J, Saeidi N, Ozer S, et al.
Sci Rep
. 2016 Mar;
6:22415.
PMID: 26935866
As donor organ shortages persist, functional machine perfusion is under investigation to improve preservation of the donor liver. The transplantation of donation after circulatory death (DCD) livers is limited by...
8.
Bruinsma B, Avruch J, Weeder P, Sridharan G, Uygun B, Karimian N, et al.
J Vis Exp
. 2015 May;
(98).
PMID: 25938299
There is currently a severe shortage of liver grafts available for transplantation. Novel organ preservation techniques are needed to expand the pool of donor livers. Machine perfusion of donor liver...
9.
Sridharan G, Choi K, Klemashevich C, Wu C, Prabakaran D, Pan L, et al.
Nat Commun
. 2014 Nov;
5:5492.
PMID: 25411059
Metabolites produced by the intestinal microbiota are potentially important physiological modulators. Here we present a metabolomics strategy that models microbiota metabolism as a reaction network and utilizes pathway analysis to...
10.
Choi K, Ghaddar B, Moya C, Shi H, Sridharan G, Lee K, et al.
PLoS One
. 2014 Jul;
9(7):e100177.
PMID: 25075860
Lipid accumulation in adipocytes reflects a balance between enzymatic pathways leading to the formation and breakdown of esterified lipids, primarily triglycerides. This balance is extremely important, as both high and...