Gareth Howell
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Explore the profile of Gareth Howell including associated specialties, affiliations and a list of published articles.
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28
Citations
831
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Recent Articles
1.
Rey C, Jones K, Stacey K, Evans A, Worboys J, Howell G, et al.
Front Immunol
. 2025 Mar;
16:1526379.
PMID: 40046047
Natural Killer (NK) cells are innate immune cells that can directly detect and kill cancer cells. Understanding the molecular determinants regulating human NK cell cytotoxicity could help harness these cells...
2.
Cook P, Brown S, Houlder E, Furlong-Silva J, Conn D, Colombo S, et al.
Nat Commun
. 2025 Jan;
16(1):928.
PMID: 39843887
Fungal spores are abundant in the environment and a major cause of asthma. Originally characterised as a type 2 inflammatory disease, allergic airway inflammation that underpins asthma can also involve...
3.
Ionescu A, Baird P, Patel S, Howell G, Hoyland J, Richardson S
JOR Spine
. 2024 Dec;
7(4):e70029.
PMID: 39717383
Background: Notochordal cells (NCs) present in the nucleus pulposus (NP) of the developing human intervertebral disc (IVD) disappear during the first decade of life. This loss coincides with the onset...
4.
Fitzsimons L, Atif-Sheikh M, Lovely J, Mueth M, Rice M, Kotredes K, et al.
bioRxiv
. 2024 Aug;
PMID: 39211110
Basal forebrain cholinergic neurons project to the hippocampus and cortex, are critical for learning and memory, and are central to the pathogenesis of Alzheimer's disease (AD). GWAS have consistently shown...
5.
Haley M, Bere L, Minshull J, Georgaka S, Garcia-Martin N, Howell G, et al.
Sci Adv
. 2024 May;
10(20):eadj3301.
PMID: 38758780
Myeloid cells are highly prevalent in glioblastoma (GBM), existing in a spectrum of phenotypic and activation states. We now have limited knowledge of the tumor microenvironment (TME) determinants that influence...
6.
Chew C, Brand O, Yamamura T, Lawless C, Morais M, Zeef L, et al.
Matrix Biol
. 2024 Feb;
127:23-37.
PMID: 38331051
Background: The kidney contains distinct glomerular and tubulointerstitial compartments with diverse cell types and extracellular matrix components. The role of immune cells in glomerular environment is crucial for dampening inflammation...
7.
Watson J, Ferguson H, Brady R, Ferguson J, Fullwood P, Mo H, et al.
Nat Commun
. 2022 Nov;
13(1):6589.
PMID: 36329028
Receptor Tyrosine Kinase (RTK) endocytosis-dependent signalling drives cell proliferation and motility during development and adult homeostasis, but is dysregulated in diseases, including cancer. The recruitment of RTK signalling partners during...
8.
Kaur N, Ruiz-Velasco A, Raja R, Howell G, Miller J, Abouleisa R, et al.
iScience
. 2022 Mar;
25(3):103973.
PMID: 35281739
Myocardial inflammation contributes to cardiomyopathy in diabetic patients through incompletely defined underlying mechanisms. In both human and time-course experimental samples, diabetic hearts exhibited abnormal ER, with a maladaptive shift over...
9.
Howell G, Bleichrodt R
Bio Protoc
. 2021 Jun;
11(8):e3993.
PMID: 34124294
Experimental results in fungal biology research are usually obtained as average measurements across whole populations of cells, whilst ignoring what is happening at the single cell level. Microscopy has allowed...
10.
Bleichrodt R, Foster P, Howell G, Latge J, Read N
mBio
. 2020 May;
11(3).
PMID: 32398317
can cause a variety of lung diseases in immunocompromised patients, including life-threatening invasive aspergillosis. There are only three main classes of antifungal drugs currently used to treat aspergillosis, and antifungal...