Galina N Nikolenko
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Explore the profile of Galina N Nikolenko including associated specialties, affiliations and a list of published articles.
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11
Citations
373
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Recent Articles
1.
Lengruber R, Delviks-Frankenberry K, Nikolenko G, Baumann J, Santos A, Pathak V, et al.
J Antimicrob Chemother
. 2011 Mar;
66(4):702-8.
PMID: 21393163
Objectives: HIV-1 reverse transcriptase (RT) mutations associated with antiviral drug resistance have been extensively characterized in the enzyme polymerase domain. Recent studies, however, have verified the involvement of the RT...
2.
Delviks-Frankenberry K, Nikolenko G, Pathak V
Viruses
. 2010 Nov;
2(7):1476-1503.
PMID: 21088701
Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and...
3.
Nikolenko G, Delviks-Frankenberry K, Pathak V
J Virol
. 2010 Mar;
84(10):5238-49.
PMID: 20219933
Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs...
4.
Delviks-Frankenberry K, Nikolenko G, Maldarelli F, Hase S, Takebe Y, Pathak V
J Virol
. 2009 Jun;
83(17):8502-13.
PMID: 19553318
We previously shown that mutations in the connection (CN) subdomain of human immunodeficiency virus type 1 (HIV-1) subtype B reverse transcriptase (RT) increase 3'-azido-3'-deoxythymidine (AZT) resistance in the context of...
5.
Delviks-Frankenberry K, Nikolenko G, Boyer P, Hughes S, Coffin J, Jere A, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(31):10943-8.
PMID: 18667707
We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test...
6.
Delviks-Frankenberry K, Nikolenko G, Barr R, Pathak V
J Virol
. 2007 Apr;
81(13):6837-45.
PMID: 17428874
We recently observed that mutations in the human immunodeficiency type 1 (HIV-1) reverse transcriptase (RT) connection domain significantly increase 3'-azido-3'-deoxythymidine (AZT) resistance up to 536 times over wild-type (WT) RT...
7.
Thomas D, Voronin Y, Nikolenko G, Chen J, Hu W, Pathak V
J Virol
. 2007 Feb;
81(9):4798-807.
PMID: 17314159
Replication of human immunodeficiency virus type 1 (HIV-1), like all organisms, involves synthesis of a minus-strand and a plus-strand of nucleic acid. Currently available PCR methods cannot distinguish between the...
8.
Nikolenko G, Delviks-Frankenberry K, Palmer S, Maldarelli F, Fivash Jr M, Coffin J, et al.
Proc Natl Acad Sci U S A
. 2006 Dec;
104(1):317-22.
PMID: 17179211
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in nucleoside reverse transcriptase inhibitor (NRTI) resistance. To explore the predictions of this...
9.
Nikolenko G, Palmer S, Maldarelli F, Mellors J, Coffin J, Pathak V
Proc Natl Acad Sci U S A
. 2005 Feb;
102(6):2093-8.
PMID: 15684061
Understanding the mechanisms of HIV-1 drug resistance is critical for developing more effective antiretroviral agents and therapies. Based on our previously described dynamic copy-choice mechanism for retroviral recombination and our...
10.
Mbisa J, Nikolenko G, Pathak V
J Virol
. 2004 Dec;
79(1):419-27.
PMID: 15596835
The RNase H primer grip of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) contacts the DNA primer strand and positions the template strand near the RNase H active...