Gaku Nagano
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Explore the profile of Gaku Nagano including associated specialties, affiliations and a list of published articles.
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12
Citations
125
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Recent Articles
1.
Shinjo H, Nagano G, Ishii S, Himeno N, Yamamoto Y, Sagawa J, et al.
J Vis Exp
. 2024 Jan;
(203).
PMID: 38251756
Protein-protein interactions (PPIs) play a pivotal role in biological phenomena, such as cellular organization, intracellular signal transduction, and transcriptional regulation. Therefore, understanding PPIs is an important starting point for further...
2.
Hiraike Y, Saito K, Oguchi M, Wada T, Toda G, Tsutsumi S, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(31):e2308750120.
PMID: 37487068
Adipose tissue is central to regulation of energy homeostasis. Adaptive thermogenesis, which relies on mitochondrial oxidative phosphorylation (Ox-Phos), dissipates energy to counteract obesity. On the other hand, chronic inflammation in...
3.
Egusa G, Ohno H, Nagano G, Sagawa J, Shinjo H, Yamamoto Y, et al.
iScience
. 2023 Jul;
26(7):107143.
PMID: 37456852
Beige adipocytes are inducible thermogenic adipocytes used for anti-obesity treatment. Beige adipocytes rapidly lose their thermogenic capacity once external cues are removed. However, long-term administration of stimulants, such as PPARγ...
4.
NFIA determines the -effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes
Hiraike Y, Tsutsumi S, Wada T, Oguchi M, Saito K, Nakamura M, et al.
iScience
. 2022 Jul;
25(8):104729.
PMID: 35874098
Thermogenic brown and beige adipocytes counteract obesity by enhancing energy dissipation via uncoupling protein-1 (Ucp1). However, the effect of genetic variation on these cells, a major source of disease susceptibility,...
5.
Kodama T, Oki K, Otagaki Y, Baba R, Okada A, Itcho K, et al.
Endocr Relat Cancer
. 2022 Jun;
29(8):495-502.
PMID: 35675123
DNA methylation and demethylation regulate the transcription of genes. DNA methylation-associated gene expression of adrenal steroidogenic enzymes may regulate cortisol production in cortisol-producing adenoma (CPA). We aimed to determine the...
6.
Nanao Y, Oki K, Kobuke K, Itcho K, Baba R, Kodama T, et al.
Mol Cell Endocrinol
. 2022 Mar;
548:111613.
PMID: 35257799
DNA methylation alteration is tissue-specific and play a pivotal role in regulating gene transcription during cell proliferation and survival. We aimed to detect genes regulated by DNA methylation, and then...
7.
Kobuke K, Oki K, Gomez-Sanchez C, Gomez-Sanchez E, Itcho K, Ohno H, et al.
Int J Mol Sci
. 2021 Oct;
22(20).
PMID: 34681640
The molecular mechanisms by which mutation-mediated cell proliferation or tumorigenesis in aldosterone-producing adenomas (APAs) have not been elucidated. First, we investigated whether the APA-associated L104R mutation stimulated cell proliferation. Second,...
8.
Baba R, Oki K, Gomez-Sanchez C, Otagaki Y, Itcho K, Kobuke K, et al.
Mol Cell Endocrinol
. 2021 Sep;
538:111456.
PMID: 34520814
The intracellular molecular mechanisms underlying the genotype of cortisol-producing adenoma (CPA) have not been fully determined. We analyzed gene expressions in CPA and the human adrenocortical cell line (HAC15 cells)...
9.
Baba R, Oki K, Itcho K, Kobuke K, Nagano G, Ohno H, et al.
ERJ Open Res
. 2020 Oct;
6(4).
PMID: 33043048
https://bit.ly/3fkopuO.
10.
Itcho K, Oki K, Gomez-Sanchez C, Gomez-Sanchez E, Ohno H, Kobuke K, et al.
Hypertension
. 2019 Dec;
75(2):492-499.
PMID: 31865789
The endoplasmic reticulum (ER) plays a pivotal role in syntheses of proteins and steroid hormones and regulation of intracellular Ca level. We aimed to investigate ER-associated genes in aldosterone-producing adenomas...