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Gael Pradel

Explore the profile of Gael Pradel including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 777
Followers 0
Related Specialties
General Medicine
Critical Care
Pharmacology
Top 10 Co-Authors
Remi Coudroy
Nicolas Terzi
Jean-Pierre Frat
Arnaud Gacouin
Stephan Ehrmann
Arnaud W Thille
Jean-Damien Ricard
Stephanie Ragot
Guillaume Lacave
Jeremy Bourenne
Published In
Am J Respir Crit Care Med
BMJ Open
Ann Intensive Care
N Engl J Med
JAMA
Affiliations
Soon will be listed here.
Recent Articles
1.
Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece
Thille A, Gacouin A, Coudroy R, Ehrmann S, Quenot J, Nay M, et al.
N Engl J Med . 2022 Oct; 387(20):1843-1854. PMID: 36286317
Background: Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to tracheal extubation than...
2.
Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial
Frat J, Quenot J, Badie J, Coudroy R, Guitton C, Ehrmann S, et al.
JAMA . 2022 Sep; 328(12):1212-1222. PMID: 36166027
Importance: The benefit of high-flow nasal cannula oxygen (high-flow oxygen) in terms of intubation and mortality in patients with respiratory failure due to COVID-19 is controversial. Objective: To determine whether...
3.
Effects of mean arterial pressure target on mottling and arterial lactate normalization in patients with septic shock: a post hoc analysis of the SEPSISPAM randomized trial
Fage N, Demiselle J, Seegers V, Merdji H, Grelon F, Megarbane B, et al.
Ann Intensive Care . 2022 Aug; 12(1):78. PMID: 35984574
Background: In patients with septic shock, the impact of the mean arterial pressure (MAP) target on the course of mottling remains uncertain. In this post hoc analysis of the SEPSISPAM...
4.
Beneficial Effects of Noninvasive Ventilation after Extubation in Obese or Overweight Patients: A Analysis of a Randomized Clinical Trial
Thille A, Coudroy R, Nay M, Gacouin A, Decavele M, Sonneville R, et al.
Am J Respir Crit Care Med . 2021 Nov; 205(4):440-449. PMID: 34813391
Although noninvasive ventilation (NIV) may prevent reintubation in patients at high risk of extubation failure in ICUs, this oxygenation strategy has not been specifically assessed in obese patients. We hypothesized...
5.
Non-invasive ventilation versus high-flow nasal oxygen for postextubation respiratory failure in ICU: a post-hoc analysis of a randomized clinical trial
Thille A, Monseau G, Coudroy R, Nay M, Gacouin A, Decavele M, et al.
Crit Care . 2021 Jun; 25(1):221. PMID: 34183053
Background: In intensive care units (ICUs), patients experiencing post-extubation respiratory failure have poor outcomes. The use of noninvasive ventilation (NIV) to treat post-extubation respiratory failure may increase the risk of...
6.
Prior Exposure to Angiotensin II Receptor Blockers in Patients With Septic Shock to Individualize Mean Arterial Pressure Target? A Post Hoc Analysis of the Sepsis and Mean Arterial Pressure (SEPSISPAM) Trial
Demiselle J, Seegers V, Lemerle M, Meziani F, Grelon F, Megarbane B, et al.
Crit Care Med . 2021 Feb; 49(4):e412-e422. PMID: 33591012
Objectives: Individualizing a target mean arterial pressure is challenging during the initial resuscitation of patients with septic shock. The Sepsis and Mean Arterial Pressure (SEPSISPAM) trial suggested that targeting high...
7.
Non-invasive ventilation alternating with high-flow nasal oxygen versus high-flow nasal oxygen alone after extubation in COPD patients: a post hoc analysis of a randomized controlled trial
Thille A, Coudroy R, Nay M, Gacouin A, Decavele M, Sonneville R, et al.
Ann Intensive Care . 2021 Feb; 11(1):30. PMID: 33559765
Background: Several randomized clinical trials have shown that non-invasive ventilation (NIV) applied immediately after extubation may prevent reintubation in patients at high-risk of extubation failure. However, most of studies included...
8.
T-piece versus pressure-support ventilation for spontaneous breathing trials before extubation in patients at high risk of reintubation: protocol for a multicentre, randomised controlled trial (TIP-EX)
Thille A, Coudroy R, Gacouin A, Ehrmann S, Contou D, Dangers L, et al.
BMJ Open . 2020 Nov; 10(11):e042619. PMID: 33234658
Introduction: In intensive care unit (ICU), the decision of extubation is a critical time because mortality is particularly high in case of reintubation. To reduce that risk, guidelines recommend to...
9.
Pressure-Support Ventilation vs T-Piece During Spontaneous Breathing Trials Before Extubation Among Patients at High Risk of Extubation Failure: A Post-Hoc Analysis of a Clinical Trial
Thille A, Coudroy R, Nay M, Gacouin A, Demoule A, Sonneville R, et al.
Chest . 2020 May; 158(4):1446-1455. PMID: 32439503
Background: Spontaneous breathing trial (SBT) using a T-piece remains the most frequently performed trial before extubation in ICUs. Research Question: We aimed at determining whether initial SBT using pressure-support ventilation...
10.
Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial
Thille A, Muller G, Gacouin A, Coudroy R, Decavele M, Sonneville R, et al.
JAMA . 2019 Oct; 322(15):1465-1475. PMID: 31577036
Importance: High-flow nasal oxygen may prevent postextubation respiratory failure in the intensive care unit (ICU). The combination of high-flow nasal oxygen with noninvasive ventilation (NIV) may be an optimal strategy...