Gael Hedou
Overview
Explore the profile of Gael Hedou including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
161
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Recent Articles
1.
Cini J, Dexter S, Rezac D, McAndrew S, Hedou G, Brody R, et al.
Front Immunol
. 2024 Jan;
14:1326927.
PMID: 38250068
Background: The potential synergy between interleukin-12 (IL-12) and IL-15 holds promise for more effective solid tumor immunotherapy. Nevertheless, previous clinical trials involving therapeutic cytokines have encountered obstacles such as short...
2.
Charvin D, Pomel V, Ortiz M, Frauli M, Scheffler S, Steinberg E, et al.
J Med Chem
. 2017 Sep;
60(20):8515-8537.
PMID: 28902994
The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson's disease (PD). However, since the discovery of its therapeutic potential, no ligand has been successfully...
3.
Cox A, Sagot Y, Hedou G, Grek C, Wilkes T, Vinik A, et al.
Front Endocrinol (Lausanne)
. 2017 May;
8:89.
PMID: 28512447
Diabetic peripheral neuropathy (DPN) remains one of the most common and serious complications of diabetes. Currently, pharmacological agents are limited to treating the pain associated with DPN, and do not...
4.
Quarta D, Valerio E, Hutcheson D, Hedou G, Heidbreder C
Neurochem Int
. 2009 Sep;
56(1):11-5.
PMID: 19737591
Orexin-expressing neurons are present in hypothalamic nuclei and send projections toward mesolimbic regions such as the nucleus accumbens (NAc), a key brain region implicated in the processing of the motivational...
5.
Quarta D, Di Francesco C, Melotto S, Mangiarini L, Heidbreder C, Hedou G
Neurochem Int
. 2009 Jan;
54(2):89-94.
PMID: 19118592
The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R) to promote foraging and feeding behaviours mainly via the hypothalamic arcuate nucleus (ARC). GHS-Rs are also expressed in midbrain dopaminergic...
6.
Jouvenceau A, Hedou G, Potier B, Kollen M, Dutar P, Mansuy I
Eur J Neurosci
. 2006 Aug;
24(2):564-72.
PMID: 16903858
Synaptic plasticity is an important cellular mechanism that underlies memory formation. In brain areas involved in memory such as the hippocampus, long-term synaptic plasticity is bidirectional. Major forms of bidirectional...
7.
Hedou G, Mansuy I
Philos Trans R Soc Lond B Biol Sci
. 2003 May;
358(1432):797-804.
PMID: 12740126
This article reviews technical and conceptual advances in unravelling the molecular bases of long-term potentiation (LTP), learning and memory using genetic approaches. We focus on studies aimed at testing a...
8.
Hedou G, Jongen-Relo A, Murphy C, Heidbreder C, Feldon J
Brain Res
. 2002 Sep;
950(1-2):165-79.
PMID: 12231241
Behavioral sensitization to the locomotor activating effects of amphetamine refers to the progressive, long lasting increase in locomotor activity that occurs with repeated injections. This phenomenon is thought to result...