Gael Castel
Overview
Explore the profile of Gael Castel including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
315
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0
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Recent Articles
1.
Alfeghaly C, Castel G, Cazottes E, Moscatelli M, Moinard E, Casanova M, et al.
Nat Struct Mol Biol
. 2024 Jun;
31(10):1589-1600.
PMID: 38834912
XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female preimplantation embryos...
2.
Castel G, David L
Nat Protoc
. 2022 Oct;
17(12):2760-2783.
PMID: 36241723
Cell reprogramming has allowed unprecedented access to human development, from virtually any genome. However, reprogramming yields pluripotent stem cells that can differentiate into all cells that form a fetus, but...
3.
Kagawa H, Javali A, Khoei H, Sommer T, Sestini G, Novatchkova M, et al.
Nature
. 2021 Dec;
601(7894):600-605.
PMID: 34856602
One week after fertilization, human embryos implant into the uterus. This event requires the embryo to form a blastocyst consisting of a sphere encircling a cavity lodging the embryo proper....
4.
Meistermann D, Bruneau A, Loubersac S, Reignier A, Firmin J, Francois-Campion V, et al.
Cell Stem Cell
. 2021 May;
28(9):1625-1640.e6.
PMID: 34004179
Understanding lineage specification during human pre-implantation development is a gateway to improving assisted reproductive technologies and stem cell research. Here we employ pseudotime analysis of single-cell RNA sequencing (scRNA-seq) data...
5.
Castel G, Meistermann D, Bretin B, Firmin J, Blin J, Loubersac S, et al.
Cell Rep
. 2020 Nov;
33(8):108419.
PMID: 33238118
Human trophoblast stem cells (hTSCs) derived from blastocysts and first-trimester cytotrophoblasts offer an unprecedented opportunity to study the placenta. However, access to human embryos and first-trimester placentas is limited, thus...