Gabriele Civiletto
Overview
Explore the profile of Gabriele Civiletto including associated specialties, affiliations and a list of published articles.
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11
Citations
848
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Recent Articles
1.
Lyu Y, Fu Q, Wilczok D, Ying K, King A, Antebi A, et al.
Aging (Albany NY)
. 2024 Oct;
16(20):12955-12976.
PMID: 39418098
The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We,...
2.
Nicol T, Falcone S, Blease A, Vikhe P, Civiletto G, Omairi S, et al.
Cardiovasc Res
. 2023 Jul;
119(12):2213-2229.
PMID: 37395010
Aims: Mitochondrial Complex I assembly (MCIA) is a multi-step process that necessitates the involvement of a variety of assembly factors and chaperones to ensure that the final active enzyme is...
3.
Gut P, Matilainen S, Meyer J, Pallijeff P, Richard J, Carroll C, et al.
Nat Commun
. 2020 Nov;
11(1):5927.
PMID: 33230181
Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial encephalomyopathy of unknown pathomechanism. Here, we show that succinyl-CoA...
4.
Migliavacca E, Tay S, Patel H, Sonntag T, Civiletto G, McFarlane C, et al.
Nat Commun
. 2019 Dec;
10(1):5808.
PMID: 31862890
The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly...
5.
Collodet C, Foretz M, Deak M, Bultot L, Metairon S, Viollet B, et al.
FASEB J
. 2019 Aug;
33(11):12374-12391.
PMID: 31404503
AMPK is a central regulator of energy homeostasis. AMPK not only elicits acute metabolic responses but also promotes metabolic reprogramming and adaptations in the long-term through regulation of specific transcription...
6.
Civiletto G, Dogan S, Cerutti R, Fagiolari G, Moggio M, Lamperti C, et al.
EMBO Mol Med
. 2018 Oct;
10(11).
PMID: 30309855
The mTOR inhibitor rapamycin ameliorates the clinical and biochemical phenotype of mouse, worm, and cellular models of mitochondrial disease, via an unclear mechanism. Here, we show that prolonged rapamycin treatment...
7.
Civiletto G, Varanita T, Cerutti R, Gorletta T, Barbaro S, Marchet S, et al.
Cell Metab
. 2015 Jun;
21(6):845-54.
PMID: 26039449
Increased levels of the mitochondria-shaping protein Opa1 improve respiratory chain efficiency and protect from tissue damage, suggesting that it could be an attractive target to counteract mitochondrial dysfunction. Here we...
8.
Varanita T, Soriano M, Romanello V, Zaglia T, Quintana-Cabrera R, Semenzato M, et al.
Cell Metab
. 2015 Jun;
21(6):834-44.
PMID: 26039448
Mitochondrial morphological and ultrastructural changes occur during apoptosis and autophagy, but whether they are relevant in vivo for tissue response to damage is unclear. Here we investigate the role of...
9.
Bottani E, Giordano C, Civiletto G, Di Meo I, Auricchio A, Ciusani E, et al.
Mol Ther
. 2013 Nov;
22(1):10-7.
PMID: 24247928
Mutations in human MPV17 cause a hepatocerebral form of mitochondrial DNA depletion syndrome (MDS) hallmarked by early-onset liver failure, leading to premature death. Liver transplantation and frequent feeding using slow-release...
10.
Viscomi C, Bottani E, Civiletto G, Cerutti R, Moggio M, Fagiolari G, et al.
Cell Metab
. 2011 Jul;
14(1):80-90.
PMID: 21723506
Increased mitochondrial biogenesis by activation of PPAR- or AMPK/PGC-1α-dependent homeostatic pathways has been proposed as a treatment for mitochondrial disease. We tested this hypothesis on three recombinant mouse models characterized...