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Gabriel Mbalaviele

Explore the profile of Gabriel Mbalaviele including associated specialties, affiliations and a list of published articles. Areas
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Articles 69
Citations 1646
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Recent Articles
1.
Swarnkar G, Naaz M, Mims D, Gupta P, Peterson T, Christopher M, et al.
Arthritis Rheumatol . 2024 Sep; 77(2):124-139. PMID: 39279148
Objective: Current therapies targeting individual factors in inflammatory arthritis show variable efficacy, often requiring treatment with combinations of drugs, and are associated with undesirable side effects. NF-ĸB is critical for...
2.
Muela-Zarzuela I, Suarez-Rivero J, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, et al.
Inflamm Res . 2024 Jun; 73(8):1253-1266. PMID: 38907167
Background: Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which...
3.
Mbalaviele G, Ryffel B
Front Immunol . 2024 Jun; 15:1420303. PMID: 38840909
No abstract available.
4.
Wang C, Kaur K, Xu C, Abu-Amer Y, Mbalaviele G
Elife . 2024 Apr; 13. PMID: 38602733
Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to...
5.
Swarnkar G, Semenkovich N, Arra M, Mims D, Naqvi S, Peterson T, et al.
Proc Natl Acad Sci U S A . 2024 Feb; 121(7):e2310264121. PMID: 38319963
Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and...
6.
Khanna K, Yan H, Mehra M, Rohatgi N, Mbalaviele G, Mellins E, et al.
Arthritis Rheumatol . 2023 Aug; 76(1):107-118. PMID: 37534578
Objective: Inflammasomes modulate the release of bioactive interleukin (IL)-1β. Excessive IL-1β levels are detected in patients with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS) with mutated and...
7.
Khanna K, Yan H, Mehra M, Rohatgi N, Mbalaviele G, Faccio R
bioRxiv . 2023 Mar; PMID: 36945522
Objective: Inflammasomes modulate the release of bioactive IL-1β. Excessive IL-1β levels are detected in patients with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS) with mutated and unmutated...
8.
Muela-Zarzuela I, Suarez-Rivero J, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, et al.
bioRxiv . 2023 Feb; PMID: 36798300
Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present...
9.
Xiao J, Sun K, Wang C, Abu-Amer Y, Mbalaviele G
J Transl Autoimmun . 2022 Sep; 5:100162. PMID: 36097634
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in...
10.
Arra M, Swarnkar G, Adapala N, Naqvi S, Cai L, Rai M, et al.
Elife . 2022 Aug; 11. PMID: 35916374
Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be...