Gabriel Ichim
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Explore the profile of Gabriel Ichim including associated specialties, affiliations and a list of published articles.
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42
Citations
1478
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Recent Articles
11.
Ichim G, Gibert B, Adriouch S, Brenner C, Davoust N, Desagher S, et al.
Biomolecules
. 2022 Jul;
12(7).
PMID: 35883457
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in , apoptosis and various other forms of regulated cell death have been thoroughly...
12.
Koessinger A, Cloix C, Koessinger D, Heiland D, Bock F, Strathdee K, et al.
Cell Death Differ
. 2022 Apr;
29(10):2089-2104.
PMID: 35473984
Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour...
13.
Cao K, Riley J, Heilig R, Montes-Gomez A, Vringer E, Berthenet K, et al.
Dev Cell
. 2022 Apr;
57(10):1211-1225.e6.
PMID: 35447090
Mitochondrial dysfunction is interconnected with cancer. Nevertheless, how defective mitochondria promote cancer is poorly understood. We find that mitochondrial dysfunction promotes DNA damage under conditions of increased apoptotic priming. Underlying...
14.
Haimovici A, Hofer C, Badr M, Haghighi E, Amer T, Boerries M, et al.
Cell Death Dis
. 2022 Apr;
13(4):315.
PMID: 35393399
Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis. The mitochondrial apoptosis apparatus can be...
15.
Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, et al.
Elife
. 2022 Mar;
11.
PMID: 35256052
Mechanical stress is known to fuel several hallmarks of cancer, ranging from genome instability to uncontrolled proliferation or invasion. Cancer cells are constantly challenged by mechanical stresses not only in...
16.
Locquet M, Ichim G, Bisaccia J, Dutour A, Lebecque S, Castets M, et al.
Sci Rep
. 2021 May;
11(1):10609.
PMID: 34011952
In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease. Here, we demonstrate that in the absence of...
17.
Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
Goldsmith C, Rodriguez-Aguilera J, El-Rifai I, Jarretier-Yuste A, Hervieu V, Raineteau O, et al.
Sci Rep
. 2021 Apr;
11(1):8032.
PMID: 33850190
Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical limitations, it has been less clear if...
18.
Serulla M, Ichim G, Stojceski F, Grasso G, Afonin S, Heulot M, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
117(50):31871-31881.
PMID: 33257567
TAT-RasGAP is a cell-penetrating peptide-based construct with anticancer and antimicrobial activities. This peptide kills a subset of cancer cells in a manner that does not involve known programmed cell death...
19.
Berthenet K, Weber K, Ichim G
Mol Cell Oncol
. 2020 Nov;
7(6):1797430.
PMID: 33235903
Apoptosis is vital for the correct morphogenesis of multi-cellular organisms. However, like most physiological programs, the cell's ability to commit suicide is hijacked by cancer in its own proliferative and...
20.
Castillo Ferrer C, Berthenet K, Ichim G
FEBS J
. 2020 Nov;
288(15):4445-4463.
PMID: 33179432
Apoptosis, the most extensively studied form of programmed cell death, is essential for organismal homeostasis. Apoptotic cell death has widely been reported as a tumor suppressor mechanism. However, recent studies...