Gabor Oroszlan
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Explore the profile of Gabor Oroszlan including associated specialties, affiliations and a list of published articles.
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9
Citations
171
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Recent Articles
1.
Shankar S, Pan J, Yang P, Bian Y, Oroszlan G, Yu Z, et al.
Cell
. 2024 Aug;
187(20):5572-5586.e15.
PMID: 39197451
DNA polymerases are important drug targets, and many structural studies have captured them in distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance...
2.
Dani R, Oroszlan G, Martinusz R, Farkas B, Dobos B, Vadas E, et al.
Front Immunol
. 2023 Jun;
14:1197023.
PMID: 37283768
Complement factor D (FD) is a serine protease present predominantly in the active form in circulation. It is synthesized as a zymogen (pro-FD), but it is continuously converted to FD...
3.
Griffante G, Gugliesi F, Pasquero S, DellOste V, Biolatti M, Salinger A, et al.
Nat Commun
. 2021 Jun;
12(1):3910.
PMID: 34162877
Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability...
4.
Oroszlan G, Dani R, Vegh B, Varga D, Acs A, Pal G, et al.
J Immunol
. 2021 Apr;
206(9):2198-2205.
PMID: 33858964
Factor D (FD) is an essential element of the alternative pathway of the complement system, and it circulates predominantly in cleaved, activated form in the blood. In resting blood, mannose-binding...
5.
Nagy Z, Szakacs D, Boros E, Heja D, Vigh E, Sandor N, et al.
PLoS Pathog
. 2019 Dec;
15(12):e1008232.
PMID: 31860690
Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major...
6.
Parej K, Kocsis A, Enyingi C, Dani R, Oroszlan G, Beinrohr L, et al.
J Immunol
. 2018 Feb;
200(7):2247-2252.
PMID: 29475986
The complement system is a sophisticated network of proteases. In this article, we describe an unexpected link between two linear activation routes of the complement system: the lectin pathway (LP)...
7.
Oroszlan G, Dani R, Szilagyi A, Zavodszky P, Thiel S, Gal P, et al.
Front Immunol
. 2018 Jan;
8:1821.
PMID: 29326707
Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced limited proteolysis by another protease or by autoactivation. The lectin pathway...
8.
Dobo J, Szakacs D, Oroszlan G, Kortvely E, Kiss B, Boros E, et al.
Sci Rep
. 2016 Aug;
6:31877.
PMID: 27535802
MASP-3 was discovered 15 years ago as the third mannan-binding lectin (MBL)-associated serine protease of the complement lectin pathway. Lacking any verified substrate its role remained ambiguous. MASP-3 was shown...
9.
Oroszlan G, Kortvely E, Szakacs D, Kocsis A, Dammeier S, Zeck A, et al.
J Immunol
. 2015 Dec;
196(2):857-65.
PMID: 26673137
It had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD lacking a propeptide is present in blood. The serum of mannose-binding...