Gabor J Tigyi
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Explore the profile of Gabor J Tigyi including associated specialties, affiliations and a list of published articles.
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38
Citations
759
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Recent Articles
1.
Rai P, Clark C, Kardam V, Womack C, Thammathong J, Norman D, et al.
Int J Mol Sci
. 2025 Jan;
26(2).
PMID: 39859312
The autotaxin-lysophosphatidic acid receptor (ATX-LPAR) signaling axis is pivotal in various clinical conditions, including cancer and autoimmune disorders. This axis promotes tumorigenicity by interacting with the tumor microenvironment, facilitating metastasis,...
2.
Dacheux M, Norman D, Shin Y, Tigyi G, Lee S
iScience
. 2024 Oct;
27(10):110971.
PMID: 39398245
Autotaxin (ATX) is a lysophospholipase D that generates lysophosphatidic acid (LPA) and regulates cancer metastasis, therapeutic resistance, and tumor immunity. We found that myeloid cells in human melanoma biopsies abundantly...
3.
Rai P, Clark C, Womack C, Dearing C, Thammathong J, Norman D, et al.
Molecules
. 2024 Sep;
29(18).
PMID: 39339280
The development of drug resistance in cancer cells poses a significant challenge for treatment, with nearly 90% of cancer-related deaths attributed to it. Over 50% of ovarian cancer patients and...
4.
Major E, Lin K, Lee S, Kaldi K, Gyorffy B, Tigyi G, et al.
Acta Pharmacol Sin
. 2024 Aug;
46(1):222-230.
PMID: 39187677
While immune checkpoint inhibitors (ICIs) are promising in the treatment of metastatic melanoma, about half of patients do not respond well to them. Low levels of human leukocyte antigen-DR (HLA-DR)...
5.
Seo E, Park S, Lee E, Huh Y, Ha Y, Tigyi G, et al.
Int J Stem Cells
. 2024 Jul;
17(3):330-336.
PMID: 38993099
Mesenchymal stem cells in the dental tissue indicate a disposition for differentiation into diverse dental lineages and contain enormous potential as the important means for regenerative medicine in dentistry. Among...
6.
Kim T, Kim A, Aryal Y, Sung S, Pokharel E, Neupane S, et al.
J Cell Physiol
. 2023 Dec;
239(1):112-123.
PMID: 38149778
Lipid biosynthesis is recently studied its functions in a range of cellular physiology including differentiation and regeneration. However, it still remains to be elucidated in its precise function. To reveal...
7.
Heo S, Keum B, Seo E, Yoon J, Jeong S, Tigyi G, et al.
J Dent Sci
. 2023 Jul;
18(3):1219-1226.
PMID: 37404649
Background/purpose: Human dental pulp stem cells (hDPSCs) possess excellent proliferative and osteogenic differentiation potentials. This study aimed to elucidate the role of lysophosphatidic acid (LPA) signaling in the proliferation and...
8.
Dacheux M, Norman D, Tigyi G, Lee S
Pharmacol Ther
. 2023 Apr;
245:108414.
PMID: 37061203
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal rearrangements, and neurite retraction. The biological...
9.
Banerjee S, Lee S, Norman D, Tigyi G
Molecules
. 2022 Sep;
27(17).
PMID: 36080255
The ATX-LPA-LPAR1 signaling pathway plays a universal role in stimulating diverse cellular responses, including cell proliferation, migration, survival, and invasion in almost every cell type. The ATX-LPAR1 axis is linked...
10.
Dacheux M, Lee S, Shin Y, Norman D, Lin K, E S, et al.
Cancers (Basel)
. 2022 Mar;
14(6).
PMID: 35326737
Although metastases are the principal cause of cancer-related deaths, the molecular aspects of the role of stromal cells in the establishment of the metastatic niche remain poorly understood. One of...