G Wickham
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Explore the profile of G Wickham including associated specialties, affiliations and a list of published articles.
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22
Citations
107
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Recent Articles
1.
Rasoul F, Ercole F, Pham Y, Bui C, Wu Z, James S, et al.
Biopolymers
. 2000 Nov;
55(3):207-16.
PMID: 11074415
Solid-phase synthesis is greatly dependent on the solid phase. We are interested in the development of a "pellicular" type of solid support where a more mobile polymer is grafted to...
2.
Weimann A, Wickham G, Sheil M
Analyst
. 2000 Jul;
125(4):627-33.
PMID: 10892019
The utility of electrospray ionisation (ESI) tandem mass spectrometry (MS/MS) for the characterisation of ligand-oligonucleotide adducts is demonstrated with adducts formed between the oligonucleotide 5'-CACGTG-3' and both a platinating agent,...
3.
Ede N, Eagle S, Wickham G, Bray A, Warne B, Shoemaker K, et al.
J Pept Sci
. 2000 Feb;
6(1):11-8.
PMID: 10674715
The solid phase synthesis of a set of peptide aldehydes derived from the NS5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrated using an oxazolidine linker and the...
4.
Pavlopoulos S, Bicknell W, Wickham G, Craik D
J Mol Recognit
. 1999 Dec;
12(6):346-54.
PMID: 10611644
Hedamycin, a member of the pluramycin class of antitumour antibiotics, consists of a planar anthrapyrantrione chromophore to which is attached two aminosugar rings at one end and a bisepoxide-containing sidechain...
5.
Whittaker J, McFadyen W, Wickham G, Wakelin L, Murray V
Nucleic Acids Res
. 1998 Aug;
26(17):3933-9.
PMID: 9705500
Cisplatin analogues were synthesised that consisted of platinum(II) diamine complexes tethered via a polymethylene chain ( n = 3, 5, 8 and 10) to a phenanthridinium cation. Both chloro and...
6.
Pavlopoulos S, Bicknell W, Craik D, Wickham G
Biochemistry
. 1996 Jul;
35(29):9314-24.
PMID: 8755709
2D NMR spectroscopic methods have been used to determine the structure of the adduct formed between the antitumor antibiotic hedamycin and the oligodeoxyribonucleotide duplex d(CACGTG)2. Evidence for both intercalation and...
7.
Murray V, Matias C, McFadyen W, Wickham G
Biochim Biophys Acta
. 1996 Feb;
1305(1-2):79-86.
PMID: 8605255
The sequence specificity of DNA damage of n-bromoalkylphenanthridinium bromides, with linker chain lengths (n) of 4,6,8 and 10 methylene groups, was investigated in the plasmid pUC8 and in intact human...
8.
Pavlopoulos S, Rose M, Wickham G, Craik D
Anticancer Drug Des
. 1995 Dec;
10(8):623-39.
PMID: 8595122
A series of terephthalamide derivatives with the substituents R = NO2, NH2 and NHCOCH2NH2 on the central aryl ring have been synthesized, and their interaction with the DNA decamer d(GGTAATTACC)2...
9.
Murray V, Moore A, Matias C, Wickham G
Biochim Biophys Acta
. 1995 Apr;
1261(2):195-200.
PMID: 7711062
The sequence specificity of the pluramycin antibiotics hedamycin and DC92-B, was established in intact human cells using a linear amplification system. In this system an oligonucleotide primer is extended by...
10.
Prakash A, Moore A, Murray V, Matias C, McFadyen W, Wickham G
Chem Biol Interact
. 1995 Mar;
95(1-2):17-28.
PMID: 7697748
The sequence selectivity of DNA alkylation by the recently isolated pluramycin antitumour antibiotic DC92-B has been investigated using two methods: a piperidine-induced strand-breaking procedure and a Taq DNA polymerase/linear amplification...