G T Macfarlane
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Explore the profile of G T Macfarlane including associated specialties, affiliations and a list of published articles.
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Articles
78
Citations
5126
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Recent Articles
1.
Arboleya S, Bahrami B, Macfarlane S, Gueimonde M, Macfarlane G, G de Los Reyes-Gavilan C
Benef Microbes
. 2015 Feb;
6(4):543-52.
PMID: 25691102
The colonisation and establishment of the intestinal microbiota starts immediately at birth and is essential for the development of the intestine and the immune system. This microbial community gradually increases...
2.
Macfarlane S, Cleary S, Bahrami B, Reynolds N, Macfarlane G
Aliment Pharmacol Ther
. 2013 Aug;
38(7):804-16.
PMID: 23957631
Background: Ageing can result in major changes in the composition and metabolic activities of bacterial populations in the large gut and an impaired immune system. Aim: To investigate the effects...
3.
Blackett K, Siddhi S, Cleary S, Steed H, Miller M, Macfarlane S, et al.
Aliment Pharmacol Ther
. 2013 Apr;
37(11):1084-92.
PMID: 23600758
Summary: Barrett's oesophagus (BO) and gastro-oesophageal reflux disease (GERD) are precursors of oesophageal adenocarcinoma (OAC). There is an oesophageal biofilm, which changes in disease, but its role in aetiopathogenesis remains...
4.
Bahrami B, Macfarlane S, Macfarlane G
J Appl Microbiol
. 2010 Nov;
110(1):353-63.
PMID: 21070518
Aims: To investigate the effects of human gut micro-organisms on cytokine production by human intestinal cell lines. Methods And Results: Quantitative real-time PCR assays were developed to measure the production...
5.
Steed H, Macfarlane G, Blackett K, Bahrami B, Reynolds N, Walsh S, et al.
Aliment Pharmacol Ther
. 2010 Aug;
32(7):872-83.
PMID: 20735782
Background: Crohn's disease is an inflammatory illness in which the immune response against gut microorganisms is believed to drive an abnormal immune response. Consequently, modification of mucosal bacterial communities, and...
6.
Macfarlane G, Macfarlane L
Dig Dis
. 2010 Mar;
27 Suppl 1:90-8.
PMID: 20203503
The gut is sterile at birth, but is rapidly colonised by faecal and vaginal bacteria of maternal origin. Over the succeeding weeks, months and years, a complex microbiota develops that...
7.
Macfarlane G, Blackett K, Nakayama T, Steed H, Macfarlane S
Curr Pharm Des
. 2009 May;
15(13):1528-36.
PMID: 19442170
Crohn's disease and ulcerative colitis are the two principal forms of inflammatory bowel disease (IBD). The root causes of these chronic and acute immunological disorders are unclear, but intestinal microorganisms...
8.
Macfarlane G, Cummings J
West J Med
. 2008 Aug;
171(3):187-91.
PMID: 18751183
No abstract available.
9.
Macfarlane G, Steed H, Macfarlane S
J Appl Microbiol
. 2008 Jan;
104(2):305-44.
PMID: 18215222
Most studies involving prebiotic oligosaccharides have been carried out using inulin and its fructo-oligosaccharide (FOS) derivatives, together with various forms of galacto-oligosaccharides (GOS). Although many intestinal bacteria are able to...
10.
Macfarlane S, Macfarlane G, Cummings J
Aliment Pharmacol Ther
. 2006 Aug;
24(5):701-14.
PMID: 16918875
Background: Prebiotics are short-chain carbohydrates that alter the composition, or metabolism, of the gut microbiota in a beneficial manner. It is therefore expected that prebiotics will improve health in a...