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G S MCCALEB

Explore the profile of G S MCCALEB including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 105
Followers 0
Related Specialties
Chemistry
Biochemistry
Oncology
Top 10 Co-Authors
J A Montgomery
T P Johnston
J R Piper
F M Sirotnak
R L Kisliuk
Y Gaumont
P S Opliger
W R LASTER
R James
F A Schmid
Published In
J Med Chem
Biochem Pharmacol
Cancer Res
Affiliations
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Recent Articles
1.
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase
Piper J, MCCALEB G, Montgomery J, Kisliuk R, Gaumont Y, Thorndike J, et al.
J Med Chem . 1988 Nov; 31(11):2164-9. PMID: 3184124
The title compounds were prepared in extensions of a general synthetic approach used earlier to prepare 5-alkyl-5-deaza analogues of classical antifolates. Wittig condensation of 2,4-diaminopyrido[2,3-d]pyrimidine-6-carboxaldehyde (2a) and its 5-methyl analogue...
2.
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid
Piper J, MCCALEB G, Montgomery J, Kisliuk R, Gaumont Y, Sirotnak F
J Med Chem . 1986 Jun; 29(6):1080-7. PMID: 2423690
Evidence indicating that modifications at the 5- and 10-positions of classical folic acid antimetabolites lead to compounds with favorable differential membrane transport in tumor vs. normal proliferative tissue prompted an...
3.
Syntheses and evaluation as antifolates of MTX analogues derived from 2, omega-diaminoalkanoic acids
Piper J, MCCALEB G, Montgomery J, Schmid F, Sirotnak F
J Med Chem . 1985 Aug; 28(8):1016-25. PMID: 4020824
Methotrexate (MTX) analogues 27a-c bearing 2, omega-diaminoalkanoic acids (ornithine and its two lower homologues) in place of glutamic acid were synthesized by routes proceeding through N2-[4-(methylamino)benzoyl]-N omega-[(1,1-dimethylethoxy)carbonyl]-2, omega-diaminoalkanoic acid ethyl...
4.
cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino] cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor
Johnston T, MCCALEB G, Rose W, Montgomery J
J Med Chem . 1984 Jan; 27(1):97-9. PMID: 6690691
cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino] cyclohexanecarboxylic acid (N-Me-cis-CCCNU) was synthesized in five steps from cis-4-aminocyclohexanecarboxylic acid via an N-tosylated intermediate. N-Me-cis-CCCNU, which is incapable of the facile decomposition that characterizes the clinically useful nitrosoureas,...
5.
A synthetic approach to poly(gamma-glutamyl) congugates of methotrexate
Piper J, MCCALEB G, Montgomery J
J Med Chem . 1983 Feb; 26(2):291-4. PMID: 6186813
Methotrexate poly(gamma-L-glutamate)s bearing two and three glutamate units above that present in methotrexate have been synthesized by extension of a previously described route used to synthesize the lower conjugate bearing...
6.
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism
Piper J, MCCALEB G, Montgomery J, Kisliuk R, Gaumont Y, Sirotnak F
J Med Chem . 1982 Jul; 25(7):877-80. PMID: 7108907
Reported antifolate activity against leukemia L1210 by N-[14-[[(2-amino-4-hydroxy-6-quinazolinyl)methyl]-propargylamino]benzoyl]]-L-glu tamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a study of the...
7.
L-Chlorozotocin
Johnston T, MCCALEB G, Anderson T, Murinson D
J Med Chem . 1979 May; 22(5):597-9. PMID: 156793
L-Chlorozotocin (2-[[[2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-L-glucose) was synthesized in seven steps from L-arabinose for comparison with chlorozotocin, which is the D enantiomorph and an antineoplastic agent with clinical potential. Purification of the intermediate 2-amino-2-deoxy-L-glucose...
8.
Comparison of the properties of metabolites of CCNU
WHEELER G, Johnston T, BOWDON B, MCCALEB G, Hill D, Montgomery J
Biochem Pharmacol . 1977 Dec; 26(24):2331-6. PMID: 145865
No abstract available.
9.
Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma
Montgomery J, MCCALEB G, Johnston T, Mayo J, Laster Jr W
J Med Chem . 1977 Feb; 20(2):291-5. PMID: 836501
The utility of the Lewis lung carcinoma as a secondary screen for the evaluation of nitrosoureas as anticancer agents has been assessed. The activity of this series of compounds was...
10.
Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents
Johnston T, MCCALEB G, Clayton S, Frye J, KRAUTH C, Montgomery J
J Med Chem . 1977 Feb; 20(2):279-90. PMID: 836500
The superior activity of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues,...