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G Melacini

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Articles 16
Citations 200
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Recent Articles
1.
Byun J, Akimoto M, VanSchouwen B, Lazarou T, Taylor S, Melacini G
Sci Adv . 2020 Jun; 6(25):eabb1250. PMID: 32596469
The functional response of a signaling system to an allosteric stimulus often depends on subcellular conditions, a phenomenon known as pluripotent allostery. For example, a single allosteric modulator, Rp-cAMPS, of...
2.
Melacini G, Boelens R, Kaptein R
J Biomol NMR . 2010 Nov; 13(1):67-71. PMID: 21080264
A pulse sequence is proposed which uses a train of band-selective pulses for the editing of slow chemical exchange-relay effects in experiments designed to study water-macromolecule interactions. Compared to previous...
3.
Glover K, Whiles J, Wood M, Melacini G, Komives E, Vold R
Biochemistry . 2001 Oct; 40(44):13137-42. PMID: 11683621
A fragment corresponding to the putative membrane-associating domain of the prion protein (residues 110-136) was analyzed in phospholipid bicelles. Prion(110-136) associated with bicelles and exhibited a lipid- and pH-dependent conformational...
4.
Whiles J, Brasseur R, Glover K, Melacini G, Komives E, Vold R
Biophys J . 2001 Feb; 80(1):280-93. PMID: 11159401
Mastoparan X (MPX: INWKGIAAMAKKLL-NH2) belongs to a family of ionophoric peptides found in wasp venom. Upon binding to the membrane, MPX increases the cell's permeability to cations leading to a...
5.
Melacini G, Bonvin A, Goodman M, Boelens R, Kaptein R
J Mol Biol . 2000 Jul; 300(5):1041-9. PMID: 10903852
The hydration of the collagen-like Ac-(Gly-Pro-Hyp)(6)-NH(2) triple-helical peptide in solution was investigated using an integrated set of high-resolution NMR hydration experiments, including different recently developed exchange-network editing methods. This approach...
6.
Melacini G, Boelens R, Kaptein R
J Biomol NMR . 2000 Mar; 15(3):189-201. PMID: 10677822
A pulse sequence is proposed to select water magnetization with enhanced specificity through a synergetic combination of several filtering principles. This approach relies on a constant-time evolution period implemented without...
7.
Spronk C, Bonvin A, Radha P, Melacini G, Boelens R, Kaptein R
Structure . 2000 Jan; 7(12):1483-92. PMID: 10647179
Background: Lactose repressor protein (Lac) controls the expression of the lactose metabolic genes in Escherichia coli by binding to an operator sequence in the promoter of the lac operon. Binding...
8.
Nooren I, Rietveld A, Melacini G, Sauer R, Kaptein R, Boelens R
Biochemistry . 1999 May; 38(19):6035-42. PMID: 10320329
The solution structure of the hyperstable MYL mutant (R31M/E36Y/R40L) of the Arc repressor of bacteriophage P22 was determined by NMR spectroscopy and compared to that of the wild-type Arc repressor....
9.
Melacini G, Kaptein R, Boelens R
J Magn Reson . 1999 Feb; 136(2):214-8. PMID: 9986764
An experimental approach for the editing of exchange-relayed NOEs in water-selective NOE experiments is presented. The proposed pulse sequence is based on the application during the NOE mixing time of...
10.
Melacini G, Feng Y, Goodman M
Biochemistry . 1997 Jul; 36(29):8725-32. PMID: 9220959
Molecular modeling and 1H-NMR were employed to study the structure and stability of collagen-like triple helices composed of Gly-Nleu-Pro repeats. The compounds studied include the acetyl analogs Ac-(Gly-Nleu-Pro)n-NH2 (where n...