G M Holmes
Overview
Explore the profile of G M Holmes including associated specialties, affiliations and a list of published articles.
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30
Citations
301
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Recent Articles
1.
Besecker E, White A, Holmes G
Neurogastroenterol Motil
. 2017 Dec;
30(4):e13258.
PMID: 29205695
Background: Patients with cervical or high-thoracic spinal cord injury (SCI) often present reduced gastric emptying and early satiety. Ghrelin provokes motility via gastric vagal neurocircuitry and ghrelin receptor agonists offer...
2.
Swartz E, Holmes G
Neurogastroenterol Motil
. 2014 Oct;
26(12):1717-29.
PMID: 25316513
Background: Clinical reports indicate that spinal cord injury (SCI) initiates profound gastric dysfunction. Gastric reflexes involve stimulation of sensory vagal fibers, which engage brainstem circuits that modulate efferent output back...
3.
Swartz E, Browning K, Travagli R, Holmes G
Neurogastroenterol Motil
. 2013 Nov;
26(2):272-82.
PMID: 24261332
Background: Vagally dependent gastric reflexes are mediated through vagal afferent fibers synapsing upon neurons of the nucleus tractus solitarius (NTS) which, in turn modulate the preganglionic parasympathetic dorsal motor nucleus...
4.
Browning K, Babic T, Holmes G, Swartz E, Travagli R
J Physiol
. 2013 Jan;
591(6):1563-80.
PMID: 23297311
Perivagal application of capsaicin (1% solution) is considered to cause a selective degeneration of vagal afferent C fibres and has been used extensively to examine the site of action of...
5.
Tong M, Qualls-Creekmore E, Browning K, Travagli R, Holmes G
Neurogastroenterol Motil
. 2010 Oct;
23(2):e69-79.
PMID: 20950355
Background: We have shown recently that our model of experimental high-thoracic spinal cord injury (T3-SCI) mirrors the gastrointestinal clinical presentation of neurotrauma patients, whereby T3-SCI animals show diminished gastric emptying...
6.
7.
Qualls-Creekmore E, Tong M, Holmes G
Neurogastroenterol Motil
. 2009 Sep;
22(2):181-5.
PMID: 19735361
Background: Gastric motility studies are frequently conducted with anaesthetized animal models. Some studies on the same animal species have reported differences in vagal control of the stomach that could not...
8.
Qualls-Creekmore E, Tong M, Holmes G
Neurogastroenterol Motil
. 2009 Jul;
22(1):62-9, e27-8.
PMID: 19566592
We have shown recently that spinal cord injury (SCI) decreases basal gastric contractions 3 days after injury. In the present study we used the [(13)C]-octanoic acid breath test and gastric...
9.
Tong M, Holmes G
Neurogastroenterol Motil
. 2009 Jan;
21(2):197-206.
PMID: 19126185
Gastric reflexes are mediated mainly by vago-vagal reflex circuits in the caudal medulla. Despite the fact that brainstem vago-vagal circuitry remains intact after spinal cord injury (SCI), patients with SCI...
10.
Hermann G, Holmes G, Rogers R
Curr Pharm Des
. 2005 Apr;
11(11):1391-409.
PMID: 15853670
The cytokine tumor necrosis factor(alpha) (TNF(alpha)) is associated with a constellation of physiological and behavioral characteristics that follow in response to infection such as fever, fatigue, listlessness, loss of appetite,...