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» Authors » G Leipnitz

G Leipnitz

Explore the profile of G Leipnitz including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 36
Citations 199
Followers 0
Related Specialties
Cardiology & Vascular Diseases
Neurology
Hematology
Top 10 Co-Authors
F Jung
M Wajner
E Wenzel
H Kiesewetter
P Scheffler
C A J Ribeiro
B Seminotti
D de la Hamette
M Kohler
A Latini
Published In
Neuroscience
Vasa Suppl
Klin Wochenschr
J Inherit Metab Dis
Folia Haematol Int Mag Klin Morphol Blutforsch
Affiliations
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Recent Articles
1.
Guanosine enhances glutamate uptake and oxidation, preventing oxidative stress in mouse hippocampal slices submitted to high glutamate levels
Nonose Y, Pieper L, da Silva J, Longoni A, Apel R, Meira-Martins L, et al.
Brain Res . 2020 Sep; 1748:147080. PMID: 32866546
Glutamate (Glu) is the main mammalian brain neurotransmitter. Concerning the glutamatergic neurotransmission, excessive levels of glutamate in the synaptic cleft are extremally harmful. This phenomenon, named as excitotoxicity is involved...
2.
Effects of season on boar semen parameters and antioxidant enzymes in the south subtropical region in Brazil
Argenti L, Parmeggiani B, Leipnitz G, Weber A, Pereira G, Bustamante-Filho I
Andrologia . 2018 Feb; PMID: 29388232
Although boar semen productivity is affected by seasonality, its effects are not equal among different regions which raise concerns regarding the profitability of boar stud farms. Therefore, the goals of...
3.
The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes
Colin-Gonzalez A, Paz-Loyola A, Serratos I, Seminotti B, Ribeiro C, Leipnitz G, et al.
Neuroscience . 2015 Oct; 310:578-88. PMID: 26431622
Several physiological processes in the CNS are regulated by the endocannabinoid system (ECS). Cannabinoid receptors (CBr) and CBr agonists have been involved in the modulation of the N-methyl-D-aspartate receptor (NMDAr)...
4.
Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias
Colin-Gonzalez A, Paz-Loyola A, Serratos I, Seminotti B, Ribeiro C, Leipnitz G, et al.
Neuroscience . 2015 Sep; 308:64-74. PMID: 26343296
The brain of children affected by organic acidemias develop acute neurodegeneration linked to accumulation of endogenous toxic metabolites like glutaric (GA), 3-hydroxyglutaric (3-OHGA), methylmalonic (MMA) and propionic (PA) acids. Excitotoxic...
5.
Reactive nitrogen species mediate oxidative stress and astrogliosis provoked by in vivo administration of phytanic acid in cerebellum of adolescent rats: A potential contributing pathomechanism of cerebellar injury in peroxisomal disorders
Borges C, Canani C, Fernandes C, Zanatta A, Seminotti B, Ribeiro C, et al.
Neuroscience . 2015 Jul; 304:122-32. PMID: 26188285
Phytanic acid (Phyt) accumulates in various peroxisomal diseases including Refsum disease (RD) and Zellweger syndrome (ZS). Since the pathogenesis of the neurological symptoms and especially the cerebellar abnormalities in these...
6.
Disruption of redox homeostasis and histopathological alterations caused by in vivo intrastriatal administration of D-2-hydroxyglutaric acid to young rats
da Rosa M, Seminotti B, Amaral A, Parmeggiani B, de Oliveira F, Leipnitz G, et al.
Neuroscience . 2014 Jul; 277:281-93. PMID: 25043325
High accumulation of D-2-hydroxyglutaric acid (D-2-HG) is the biochemical hallmark of patients affected by the inherited neurometabolic disorder D-2-hydroxyglutaric aciduria (D-2-HGA). Clinically, patients present neurological symptoms and basal ganglia injury...
7.
Disruption of redox homeostasis and brain damage caused in vivo by methylmalonic acid and ammonia in cerebral cortex and striatum of developing rats
Viegas C, Zanatta A, Grings M, Hickmann F, Monteiro W, Soares L, et al.
Free Radic Res . 2014 Mar; 48(6):659-69. PMID: 24580146
Hyperammonemia is a common finding in children with methylmalonic acidemia and propionic acidemia, but its contribution to the development of the neurological symptoms in the affected patients is poorly known....
8.
Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver
da Rosa M, Seminotti B, Amaral A, Fernandes C, Gasparotto J, Moreira J, et al.
Free Radic Res . 2013 Oct; 47(12):1066-75. PMID: 24127998
3-Hydroxy-3-methylglutaryl-CoA lyase (HL) deficiency is a disorder biochemically characterized by the predominant accumulation of 3-hydroxy-3-methylglutarate (HMG), 3-methylglutarate (MGA), 3-methylglutaconate and 3-hydroxyisovalerate in tissues and biological fluids of the affected patients....
9.
Evidences that maternal swimming exercise improves antioxidant defenses and induces mitochondrial biogenesis in the brain of young Wistar rats
Marcelino T, Longoni A, Kudo K, Stone V, Rech A, de Assis A, et al.
Neuroscience . 2013 May; 246:28-39. PMID: 23639877
Physical exercise during pregnancy has been considered beneficial to mother and child. Recent studies showed that maternal swimming improves memory in the offspring, increases hippocampal neurogenesis and levels of neurotrophic...
10.
Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice
Latini A, Scussiato K, Leipnitz G, Gibson K, Wajner M
J Inherit Metab Dis . 2007 Sep; 30(5):800-10. PMID: 17885820
Animal models of inborn errors of metabolism are useful for investigating the pathogenesis associated with the corresponding human disease. Since the mechanisms involved in the pathophysiology of succinate semialdehyde dehydrogenase...