G Krennrich
Overview
Explore the profile of G Krennrich including associated specialties, affiliations and a list of published articles.
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15
Citations
165
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Recent Articles
1.
Behr C, Kamp H, Fabian E, Krennrich G, Mellert W, Peter E, et al.
Arch Toxicol
. 2017 Mar;
91(10):3439-3454.
PMID: 28337503
The intestinal microbiota contributes to the metabolism of its host. Adequate identification of the microbiota's impact on the host plasma metabolites is lacking. As antibiotics have a profound effect on...
2.
Fabian E, Bordag N, Herold M, Kamp H, Krennrich G, Looser R, et al.
Toxicol Lett
. 2016 May;
255:11-23.
PMID: 27153797
The MetaMap(®)-Tox database contains plasma-metabolome and toxicity data of rats obtained from oral administration of 550 reference compounds following a standardized adapted OECD 407 protocol. Here, metabolic profiles for aniline...
3.
van Ravenzwaay B, Montoya G, Fabian E, Herold M, Krennrich G, Looser R, et al.
Toxicol Lett
. 2014 Mar;
227(1):20-8.
PMID: 24657160
The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of "omics" technologies into toxicological research, the question arises...
4.
Montoya G, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, et al.
Toxicol Lett
. 2013 Dec;
225(2):240-51.
PMID: 24370789
For identification of toxicological modes of action (MoAs) a database (MetaMap(®)Tox) was established containing plasma metabolome consisting of approximately 300 endogenous metabolites. Each five male and female Wistar rats per...
5.
Mattes W, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, et al.
Biomed Res Int
. 2013 Jun;
2013:202497.
PMID: 23762827
Addressing safety concerns such as drug-induced kidney injury (DIKI) early in the drug pharmaceutical development process ensures both patient safety and efficient clinical development. We describe a unique adjunct to...
6.
Kamp H, Strauss V, Wiemer J, Leibold E, Walk T, Mellert W, et al.
Toxicol Lett
. 2012 Oct;
215(2):143-9.
PMID: 23103988
BASF has developed a rat plasma metabolomics database (MetaMap®Tox) containing the metabolome of more than 500 chemicals, agrochemicals and drugs, for which the toxicity is well known, derived from 28-day...
7.
Kamp H, Fabian E, Groeters S, Herold M, Krennrich G, Looser R, et al.
Bioanalysis
. 2012 Oct;
4(18):2291-301.
PMID: 23046269
BASF and Metanomics have built-up the database MetaMap(®)-Tox containing rat plasma metabolome data for more than 500 reference compounds. Phenytoin was administered to five Wistar rats of both sexes at...
8.
Strauss V, Mellert W, Wiemer J, Leibold E, Kamp H, Walk T, et al.
Toxicol Lett
. 2012 Apr;
211(2):187-200.
PMID: 22484644
Combination therapies with fibrates and statins are used to treat cardiovascular diseases, because of their synergistic effect on lowering plasma lipids. However, fatal side-effects like rhabdomyolysis followed by acute renal...
9.
van Ravenzwaay B, Herold M, Kamp H, Kapp M, Fabian E, Looser R, et al.
Mutat Res
. 2012 Feb;
746(2):144-50.
PMID: 22305969
BASF has developed a Metabolomics database (MetaMap(®) Tox) containing approximately 500 data rich chemicals, agrochemicals and drugs. This metabolome-database has been built based upon 28-day studies in rats (adapted to...
10.
Mellert W, Kapp M, Strauss V, Wiemer J, Kamp H, Walk T, et al.
Toxicol Lett
. 2011 Sep;
207(2):173-81.
PMID: 21907771
Metabolite profiling (metabolomics) elucidates changes in biochemical pathways under various conditions, e.g., different nutrition scenarios or compound administration. BASF and metanomics have obtained plasma metabolic profiles of approximately 500 compounds...