G H Goossens
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Explore the profile of G H Goossens including associated specialties, affiliations and a list of published articles.
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25
Citations
850
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Recent Articles
1.
Van Meijel R, Venema K, Canfora E, Blaak E, Goossens G
Benef Microbes
. 2022 Jul;
13(4):355-364.
PMID: 35866596
Results from high altitude studies in humans and controlled animal experiments suggest that hypoxia exposure induces alterations in gut microbiota composition, which may in turn affect host metabolism. However, well-controlled...
2.
A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women
Vogel M, Wang P, Bouwman F, Hoebers N, Blaak E, Renes J, et al.
Sci Rep
. 2019 Mar;
9(1):4202.
PMID: 30862933
Body fat distribution is an important determinant of cardiometabolic health. Lower-body adipose tissue (AT) has protective characteristics as compared to upper-body fat, but the underlying depot-differences remain to be elucidated....
3.
Verboven K, Wouters K, Gaens K, Hansen D, Bijnen M, Wetzels S, et al.
Sci Rep
. 2018 Mar;
8(1):4677.
PMID: 29549282
Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR). We investigated whether AT...
4.
Stinkens R, van der Kolk B, Jordan J, Jax T, Engeli S, Heise T, et al.
Sci Rep
. 2018 Mar;
8(1):3933.
PMID: 29500454
Increased activation of the renin-angiotensin system is involved in the onset and progression of cardiometabolic diseases, while natriuretic peptides (NP) may exert protective effects. We have recently demonstrated that sacubitril/valsartan...
5.
Baumgartner S, Reijnders D, Konings M, Groen A, Lutjohann D, Goossens G, et al.
Chem Phys Lipids
. 2017 Jun;
207(Pt B):239-245.
PMID: 28647339
Background: Changes in the microbiota composition have been implicated in the development of obesity and type 2 diabetes. However, not much is known on the involvement of gut microbiota in...
6.
Most J, Goossens G, Reijnders D, Canfora E, Penders J, Blaak E
Benef Microbes
. 2017 Jun;
8(4):557-562.
PMID: 28618864
Gut microbiota composition may play an important role in the development of obesity-related comorbidities. However, only few studies have investigated gender-differences in microbiota composition and gender-specific associations between microbiota or...
7.
Most J, Penders J, LUCCHESI M, Goossens G, Blaak E
Eur J Clin Nutr
. 2017 Jun;
71(9):1040-1045.
PMID: 28589947
Background/objectives: The intestinal microbiota may have a profound impact on host metabolism. As evidence suggests that polyphenols affect substrate utilization, the present study aimed to investigate the effects of polyphenol...
8.
Vink R, Roumans N, cajlakovic M, Cleutjens J, Boekschoten M, Fazelzadeh P, et al.
Int J Obes (Lond)
. 2017 Feb;
41(5):722-728.
PMID: 28179648
Background/objectives: Although adipose tissue (AT) hypoxia is present in rodent models of obesity, evidence for this in humans is limited. Here, we investigated the effects of diet-induced weight loss (WL)...
9.
Jordan J, Stinkens R, Jax T, Engeli S, Blaak E, May M, et al.
Clin Pharmacol Ther
. 2016 Aug;
101(2):254-263.
PMID: 27542885
Natriuretic peptide (NP) deficiency and sustained renin-angiotensin system activation are associated with impaired oxidative metabolism and predispose to type-2 diabetes. We hypothesized that sacubitril/valsartan (LCZ696), which augments NP through neprilysin...
10.
Jocken J, Goossens G, Popeijus H, Essers Y, Hoebers N, Blaak E
Int J Obes (Lond)
. 2015 Oct;
40(3):507-13.
PMID: 26471343
Background/objectives: Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are key enzymes involved in intracellular lipid catabolism. We have previously shown decreased expression and activity of these lipases in adipose...