G David Ledney
Overview
Explore the profile of G David Ledney including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
333
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Recent Articles
1.
Elliott T, Bolduc D, Ledney G, Kiang J, Fatanmi O, Wise S, et al.
Int J Radiat Biol
. 2015 May;
91(9):690-702.
PMID: 25994812
Purpose: A combination therapy for combined injury (CI) using a non-specific immunomodulator, synthetic trehalose dicorynomycolate and monophosphoryl lipid A (STDCM-MPL), was evaluated to augment oral antimicrobial agents, levofloxacin (LVX) and...
2.
Bolduc D, Villa V, Sandgren D, Ledney G, Blakely W, Bunger R
Comput Math Methods Med
. 2014 Aug;
2014:685286.
PMID: 25165485
Multivariate radiation injury estimation algorithms were formulated for estimating severe hematopoietic acute radiation syndrome (H-ARS) injury (i.e., response category three or RC3) in a rhesus monkey total-body irradiation (TBI) model....
3.
Kiang J, Ledney G
Oxid Med Cell Longev
. 2013 Nov;
2013:821541.
PMID: 24175013
Skin injuries such as wounds or burns following whole-body γ-irradiation (radiation combined injury (RCI)) increase mortality more than whole-body γ-irradiation alone. Wound-induced decreases in survival after irradiation are triggered by...
4.
Kiang J, Garrison B, Burns T, Zhai M, Dews I, Ney P, et al.
Cell Biosci
. 2012 Jun;
2(1):20.
PMID: 22686656
Background: Wounding following whole-body γ-irradiation (radiation combined injury, RCI) increases mortality. Wounding-induced increases in radiation mortality are triggered by sustained activation of inducible nitric oxide synthase pathways, persistent alteration of...
5.
Cary L, Ngudiankama B, Salber R, Ledney G, Whitnall M
Radiat Res
. 2012 Apr;
177(5):663-75.
PMID: 22468705
The detonation of a nuclear weapon or a nuclear accident represent possible events with significant exposure to mixed neutron/γ-radiation fields. Although radiation countermeasures generally have been studied in subjects exposed...
6.
Kiang J, Jiao W, Cary L, Mog S, Elliott T, Pellmar T, et al.
Radiat Res
. 2010 Mar;
173(3):319-32.
PMID: 20199217
Abstract Although it is documented that concurrent wounding increases mortality from radiation injury, the molecular mechanism of combined injury is unknown. In this study, mice were exposed to gamma radiation...
7.
Ledney G, Elliott T
Health Phys
. 2010 Jan;
98(2):145-52.
PMID: 20065676
Combined injuries, which are expected after a radiation dispersal device release or nuclear weapon detonation, are the combination of radiation exposure and tissue injuries from blast and thermal energy. To...
8.
DiCarlo A, Hatchett R, Kaminski J, Ledney G, Pellmar T, Okunieff P, et al.
Radiat Res
. 2008 May;
169(6):712-21.
PMID: 18494548
Non-clinical human radiation exposure events such as the Hiroshima and Nagasaki bombings or the Chernobyl accident are often coupled with other forms of injury, such as wounds, burns, blunt trauma,...
9.
Parra N, Ege C, Ledney G
Comp Med
. 2007 Jul;
57(3):298-304.
PMID: 17605346
Profound neutropenia that provides an opportunity for infections to develop into sepsis remains an important cause of morbidity and mortality in patients after irradiation. Human clinical studies find extremely low...
10.
Hong H, Landauer M, Foriska M, Ledney G
J Basic Microbiol
. 2006 Jul;
46(4):329-35.
PMID: 16847837
Genistein, a radioprotective soy isoflavone and protein kinase inhibitor, blocks the invasion of pathogenic bacteria in mammalian epithelial cells. The purpose of this study was to evaluate the direct effect...